Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development
Satoshi Shakado, Shotaro Sakisaka, Department of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka University, Fukuoka City, Fukuoka 814-0180, Japan
Kazuaki Chayama, Department of Gastroenterology and Metabolism, Applied Life Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima City, Hiroshima 734-8553, Japan
Takeshi Okanoue, Center of Gastroenterology and Hepatology, Saiseikai Suita Hospital, Suita City, Osaka 564-0013, Japan
Joji Toyoda, Department of Gastroenterology and Hepatology, Sapporo Kousei Hospital, Sapporo City, Hokkaido 060-0033, Japan
Namiki Izumi, Department of Gastroenterology and Hepatology, Musashino Red-Cross Hospital, Musashino City, Tokyo 180-8610, Japan
Akihiro Matsumoto, Department of Medicine, Shinshu University School of Medicine, Matsumoto City, Nagano 390-8621, Japan
Tetsuo Takehara, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita City, Osaka 565-0871, Japan
Akio Ido, Department of Gastroenterology and Hepatology, Kagoshima University, Kagoshima City, Kagoshima 890-8520, Japan
Yoichi Hiasa, Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon City, Ehime 791-0295, Japan
Kentaro Yoshioka, Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health University, Toyoake City, Aichi 470-1192, Japan
Hideyuki Nomura, the Center for Liver Disease, Shin-Kokura Hospital, Kitakyushu City, Fukuoka 803-8505, Japan
Yoshiyuki Ueno, Department of Gastroenterology, Yamagata University, Yamagata City, Yamagata 990-9585, Japan
Masataka Seike, Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu City, Oita 879-5593, Japan
Hiromitsu Kumada, Department of Hepatology, Toranomon Hospital, Kawasaki City, Kanagawa 213-8587, Japan
Author contributions: Shakado S and Sakisaka S performed the study design, acquisition, analysis and interpretation of data, literature search, drafting of the manuscript; Chayama K, Okanoue T, Toyoda J, Izumi N, Matsumoto A, Takehara T, Ido A, Hiasa Y, Yoshioka K, Nomura H, Ueno Y, Seike M and Kumada H contributed to the acquisition of data.
Supported by A Grant-in-Aid from the Japanese Ministry of Health, Welfare and Labour.
Institutional review board statement: The study was not needed to approve by the institutional review board.
Informed consent statement: This study is a retrospective report. The additional informed consent from the patients does not apply.
Conflict-of-interest statement: Shotaro Sakisaka received Research Fund from MSD; Kazuaki Chayama received Research Fund from AbbVie, Dainippon Sumitomo, Janssen, Daiichi Sankyo, Roche, MSD, Toray, Otsuka and Tanabe; and Kazuaki Chayama received lecture fees form MSD and Bristol-Myers; Namiki Izumi received lecture fees from Chugai, MSD, Bristol-Myers, Dainippon Sumitomo, Janssen; Tetsuo Takehara received Research Fund from MSD; and Tetsuo Takehara received lecture fees form MSD; Akio Ido received Research Fund from Chugai, MSD, Dai-ichi Sankyo and Tanabe; Kentaro Yoshioka received Research Fund from MSD; and Kentaro Yoshioka had an advisory role to Sanwa Kagaku Kenkyusho; Yoshiyuki Ueno received Research Fund from Tanabe, MSD, Chugai, BMS and Gilead Sciences; Hiromitsu Kumada received lecture fees from MSD K.K, Bristol-Myers Squibb, Janssn Pharmaceutical K.K, Glaxo Smith Kline K.K; and Hiromitsu Kumada had patentroyalties from SRL.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Satoshi Shakado, MD, Associate Professor, Department of Gastroenterology and Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka City, Fukuoka 814-0180, Japan. firstname.lastname@example.org
Telephone: +81-92-8011011 Fax: +81-92-8742663
Received: May 30, 2015
Peer-review started: June 1, 2015
First decision: July 6, 2015
Revised: August 27, 2015
Accepted: November 13, 2015
Article in press: November 17, 2015
Published online: November 28, 2015