Retrospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Nov 28, 2015; 7(27): 2749-2756
Published online Nov 28, 2015. doi: 10.4254/wjh.v7.i27.2749
Vitamin E reduces liver stiffness in nonalcoholic fatty liver disease
Aiko Fukui, Naoto Kawabe, Senju Hashimoto, Michihito Murao, Takuji Nakano, Hiroaki Shimazaki, Toshiki Kan, Kazunori Nakaoka, Masashi Ohki, Yuka Takagawa, Tomoki Takamura, Hiroyuki Kamei, Kentaro Yoshioka
Aiko Fukui, Naoto Kawabe, Senju Hashimoto, Michihito Murao, Takuji Nakano, Hiroaki Shimazaki, Toshiki Kan, Kazunori Nakaoka, Masashi Ohki, Yuka Takagawa, Tomoki Takamura, Kentaro Yoshioka, Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health University, Aichi 470-1192, Japan
Aiko Fukui, Hiroyuki Kamei, Department of Clinical Pharmacy Practice and Health Care Management, Faculty of Pharmacy, Meijo University, Aichi 468-8503, Japan
Author contributions: Fukui A proposed the study; Kawabe N, Hashimoto S, Murao M, Nakano T, Shimazaki H, Kan T, Nakaoka M, Ohki M, Takagawa Y, Takamura T and Yoshioka K performed the research; Fukui A collected and analyzed the data; Fukui A, Kawabe N, Kamei H and Yoshioka K contributed to the design and interpretation of the study and to further drafts; Yoshioka K is the guarantor; all authors contributed equally to this work.
Institutional review board statement: This study conformed to the Japanese Good Clinical Practice and the Declaration of Helsinki, and was reviewed and approved by the Ethics Committee of the Fujita Health University Hospital (IRB number: 14-020).
Informed consent statement: Each patient gave a written informed consent.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Kentaro Yoshioka, MD, Department of Liver, Biliary Tract and Pancreas Diseases, Fujita Health University, 1-98 Dengakugakubo, Kutsukake, Toyoake, Aichi 470-1192, Japan. kyoshiok@fujita-hu.ac.jp
Telephone: +81-562-932324 Fax: +81-562-938601
Received: July 3, 2015
Peer-review started: July 6, 2015
First decision: September 8, 2015
Revised: September 20, 2015
Accepted: November 10, 2015
Article in press: November 11, 2015
Published online: November 28, 2015
Processing time: 147 Days and 6.6 Hours
Core Tip

Core tip: Responses to vitamin E treatment in nonalcoholic fatty liver disease patients were assessed by noninvasive scoring systems of hepatic fibrosis, and liver stiffness (velocity of shear wave) was measured by acoustic radiation force impulse elastography. Vitamin E treatment for 1 year improved not only liver enzyme levels but also noninvasive fibrosis scores and liver stiffness. Subsequently, the patients were divided into two groups according to patatin-like phospholipase domain containing 3 (PNPLA3) genotype (CC/CG or GG) to examine whether either group responded differently to the treatment. The responses were similar between different PNPLA3 genotypes.