Observational Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Jun 27, 2024; 16(6): 920-931
Published online Jun 27, 2024. doi: 10.4254/wjh.v16.i6.920
Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase
De-Liang Huang, Qin-Xian Cai, Guang-De Zhou, Hong Yu, Zhi-Bin Zhu, Jing-Han Peng, Jun Chen
De-Liang Huang, Qin-Xian Cai, Zhi-Bin Zhu, Jing-Han Peng, Jun Chen, Department of Liver Diseases, The Third People’s Hospital of Shenzhen, Shenzhen 510000, Guangdong Province, China
Guang-De Zhou, Department of Pathology, Beijing Youan Hospital, Capital Medical University, Beijing 100000, China
Hong Yu, Department of Pathology, National Clinical Research Centre for Infectious Disease, The Third People's Hospital of Shenzhen and the Second Hospital Affiliated with the Southern University of Science and Technology, Shenzhen 518112, Guangdong Province, China
Author contributions: Chen J and Huang DL conceptualized and designed the study, received grant support, had full access to the data, and are responsible for the integrity and accuracy of data analysis; Huang DL analyzed the data; Huang DL, Cai QX, Peng JH, Zhou GD, Yu H and Zhu ZB contributed to the writing of the report. All authors contributed to data acquisition, data interpretation and reviewed and approved the final version. All authors have read and approve the final manuscript.
Supported by Construction of Key Medical Disciplines in Shenzhen, No. SZXK076.
Institutional review board statement: The study was approved by the Ethics Committee of the Third People’s Hospital of Shenzhen (Approval No. 2022-003).
Informed consent statement: Informed consent was waived by our Institutional Review Board because of the retrospective nature of our study.
Conflict-of-interest statement: All authors declare no conflict of interest.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun Chen, PhD, Professor, Department of Liver Diseases, The Third People’s Hospital of Shenzhen, No. 29 Shenzhen Long Gang Bulan Road, Shenzhen 510000, Guangdong Province, China. drchenjun@163.com
Received: February 8, 2024
Revised: April 28, 2024
Accepted: May 17, 2024
Published online: June 27, 2024
Processing time: 132 Days and 12.9 Hours
Core Tip

Core Tip: In this study, we investigated liver histological changes in 814 chronic hepatitis B patients in the indeterminate phase, in which significant liver histological changes (defined as biopsy score ≥ G2 and/or ≥ S2) were found in 488/814 (59.95%) patients, which suggested that additional strategies are urgently required for management of these patients.