Published online Jun 27, 2024. doi: 10.4254/wjh.v16.i6.920
Revised: April 28, 2024
Accepted: May 17, 2024
Published online: June 27, 2024
Processing time: 132 Days and 12.9 Hours
Studies with large size samples on the liver histological changes of indeterminate phase chronic hepatitis B (CHB) patients were not previously conducted.
To assess the liver histological changes in the indeterminate phase CHB patients using liver biopsy.
The clinical and laboratory data of 1532 untreated CHB patients were collected, and all patients had least once liver biopsy from January 2015 to December 2021. The significant differences among different phases of CHB infection were compared with t-test, and the risk factors of significant liver histological changes were analyzed by the multivariate logistic regression analysis.
Among 1532 untreated CHB patients, 814 (53.13%) patients were in the indeter
Our results suggested that significant liver histological changes were not rare among the untreated CHB patients in indeterminate phase, and additional strategies are urgently required for the management of these patients.
Core Tip: In this study, we investigated liver histological changes in 814 chronic hepatitis B patients in the indeterminate phase, in which significant liver histological changes (defined as biopsy score ≥ G2 and/or ≥ S2) were found in 488/814 (59.95%) patients, which suggested that additional strategies are urgently required for management of these patients.