Combined hepatocellular cholangiocarcinoma: A clinicopathological update

doi:10.4254/wjh.v16.i5.766

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World Journal of Hepatology

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1948-5182

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World J Hepatol. May 27, 2024; 16(5): 766-775
Published online May 27, 2024. doi: 10.4254/wjh.v16.i5.766

Combined hepatocellular cholangiocarcinoma: A clinicopathological update

Mukul Vij, Fadl H Veerankutty, Ashwin Rammohan, Mohamed Rela

Mukul Vij, Department of Pathology, Institute of Liver Disease and Transplantation, Chennai 600044, India

Fadl H Veerankutty, Comprehensive Liver Care Institute, VPS Lakeshore, Cochin 682040, India

Fadl H Veerankutty, Ashwin Rammohan, Mohamed Rela, Institute of Liver Disease and Transplantation, Dr. Rela Institute and Medical Centre, Chennai 600044, India

Author contributions: Veerankutty FH and Vij M conceptualized the study and collected the data and contributed to manuscript preparation; Vij M, Veerankutty FH, Rammohan A and Rela M drafted and edited the manuscript.

Conflict-of-interest statement: There is no conflict of interest.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Fadl H Veerankutty, MBBS, MS, FMAS, DrNB (GI Surgery), Senior Consultant and Program Director, Comprehensive Liver Care Institute, VPS Lakeshore, NH 66, Nettoor, Maradu, Cochin 682040, India. write2drfadl@gmail.com

Received: December 4, 2023
Revised: January 31, 2024
Accepted: April 9, 2024
Published online: May 27, 2024
Processing time: 169 Days and 23.4 Hours

Core Tip

Core Tip: Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) represents a poorly understood rare primary liver tumor with a gruesome prognosis. Molecular and genetic characterization of this disease is vital for exploring newer treatment modalities to improve the survival of patients afflicted with this rare entity. In this review, we give an account of the recent developments in the pathology, diagnostic approach, and management of cHCC-CCA.