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World J Hepatol. Apr 27, 2023; 15(4): 441-459
Published online Apr 27, 2023. doi: 10.4254/wjh.v15.i4.441
COVID-19 and liver injury: Pathophysiology, risk factors, outcome and management in special populations
Romina Roshanshad, Amirhossein Roshanshad, Reza Fereidooni, Mahnaz Hosseini-Bensenjan
Romina Roshanshad, Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz 7184731443, Iran
Amirhossein Roshanshad, Department of MPH, Shiraz University of Medical Sciences, Shiraz 7184731443, Iran
Reza Fereidooni, Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran
Mahnaz Hosseini-Bensenjan, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran
Author contributions: Roshanshad R, Roshanshad A, and Fereidooni R collected data; Roshanshad R, Roshanshad A, Fereidooni R, and Hosseini-Bensenjan M drafted the paper's first version; Roshanshad R and Roshanshad A designed, revised, and finalized the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Amirhossein Roshanshad, MD, Postdoctoral Fellow, Research Fellow, Department of MPH, School of Medicine, Shiraz University of Medical Sciences, Zand Street, Shiraz 7184731443, Iran.
Received: September 28, 2022
Peer-review started: September 28, 2022
First decision: January 3, 2023
Revised: February 5, 2023
Accepted: March 20, 2023
Article in press: March 20, 2023
Published online: April 27, 2023
Core Tip

Core Tip: Severe acute respiratory syndrome coronavirus-2 can involve the liver and cause damage through different mechanisms. Liver injury can be diagnosed based on alterations in the liver function tests, which can also predict the disease severity and fatality. In patients without underlying liver disease, liver injury is typically mild and can be treated with supportive care. However, it requires additional awareness and appropriate therapy in patients with chronic liver diseases, including autoimmune hepatitis, viral hepatitis, liver cirrhosis, liver transplantation, and nonalcoholic fatty liver disease, which we have discussed in detail.