Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Hepatol. Dec 27, 2023; 15(12): 1272-1283
Published online Dec 27, 2023. doi: 10.4254/wjh.v15.i12.1272
Cell-type specific role of autophagy in the liver and its implications in non-alcoholic fatty liver disease
Sana Raza, Sangam Rajak, Rajani Singh, Jin Zhou, Rohit A Sinha, Amit Goel
Sana Raza, Sangam Rajak, Rohit A Sinha, Department of Endocrinology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Uttar Pradesh, Lucknow 226014, India
Rajani Singh, Amit Goel, Department of Hepatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Uttar Pradesh, Lucknow 226014, India
Jin Zhou, CVMD, Duke-NUS Medical School, Singapore 169857, Singapore
Co-corresponding authors: Rohit A Sinha and Amit Goel.
Author contributions: Raza S and Sinha RA reviewed and analyzed the literature, and wrote the overall manuscript; Rajak S, Singh R, Zhou J collected and reviewed the literature; Sinha RA and Goel A contributed equally to the overall intellectual input, review of the literature, and approved the manuscript. These authors helped with the synthesis of information and were the primary point of contact during the publication process.
Supported by Wellcome Trust/DBT India Alliance Fellowship, No. IA/I/16/2/502691; SERB, No. CRG/2022/002149; Young Scientist Grant, No. YSS/2020/000009/PRCYSS.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Amit Goel, BSc, DNB, MBBS, MD, MNAMS, Professor, Department of Hepatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow-226014, Uttar Pradesh, India. agoel.ag@gmail.com
Received: September 25, 2023
Peer-review started: September 25, 2023
First decision: November 3, 2023
Revised: November 7, 2023
Accepted: December 8, 2023
Article in press: December 8, 2023
Published online: December 27, 2023
Processing time: 90 Days and 18.7 Hours
Core Tip

Core Tip: This review presents a succinct overview of the cell-specific distinct effects of autophagy modulation on hepatic pathophysiology and its implication on the progression of non-alcoholic fatty liver disease (NAFLD). The effects of autophagy alteration on hepatocyte lipid metabolism, macrophage polarization and hepatic stellate cell plasticity are reviewed and discussed with reference to NAFLD pathobiology.