Published online May 27, 2020. doi: 10.4254/wjh.v12.i5.220
Peer-review started: January 1, 2020
First decision: February 19, 2020
Revised: March 30, 2020
Accepted: April 7, 2020
Article in press: April 7, 2020
Published online: May 27, 2020
Non-invasive and rapid testing of liver disease for chronic hepatitis patients is crucial given its high prevalence in Vietnam.
Liver disease can be managed properly with timely treatment and control. Mac-2 binding protein glycosylation isomer (M2BPGi) offers the capability to stage fibrosis severity quickly and assess treatment response with longitudinal measurements.
This study aims to compare M2BPGi, a blood-based biomarker with existing methods of non-invasive testing and elastography in chronic hepatitis. In a preliminary assessment of treatment response, hepatitis B DNA concentrations were correlated with M2BPGi levels in respective patients.
In patients with liver disease of different etiologies, M2BPGi levels in residual blood samples were measured. Comparisons with transient elastography (TE) were made to establish preliminary clinical cut-offs. Pearson correlations were tested using different liver disease markers to establish any significant trends. M2BPGi levels in early disease patients were compared to show etiology specificity.
We established clear correlations between M2BPGi with TE and other non-invasive biomarkers. For fibrosis staging of both hepatitis B and C patients, we observed statistically significant correlations with M2BPGi. M2BPGi levels in early disease were higher in viral hepatitis patients indicating the need to establish different cut-offs. The results were also significantly correlated with hepatitis B viral load, which established the possibility of treatment assessment.
M2BPGi level is a useful addition to the current routine assessment of chronic hepatitis patients. This is performed by a routine immunoassay that enables fast turnaround time and quicker reporting for patients.
We envision this research to have clinical potential to improve treatment monitoring procedures and rapid assessment of liver disease. In a resource limited setting, this marker presents useful results to ensure patients are linked to care promptly.