Published online May 27, 2020. doi: 10.4254/wjh.v12.i5.220
Peer-review started: January 1, 2020
First decision: February 19, 2020
Revised: March 30, 2020
Accepted: April 7, 2020
Article in press: April 7, 2020
Published online: May 27, 2020
Early diagnosis is critical for successful intervention before liver disease progresses to cirrhosis and hepatocellular carcinoma.
To examine a novel biomarker for probing early liver disease quickly using an automated immunology system.
This was a cross-sectional study. 140 patients at various stages of liver disease were randomly selected. The cohort consisted of patients who were treatment naïve and currently undergoing therapy. We included patients with diverse liver disease etiologies. Mac-2 binding protein glycosylation isomer (M2BPGi) levels in addition to different clinical parameters, co-morbidities and transient elastography results were collected and compared.
M2BPGi levels were significantly correlated with transient elastography for liver fibrosis staging across all disease etiologies. Statistically significant differences were observed in patients with F0-1; F2 and > F3 liver fibrosis. Further examination showed that M2BPGi levels were two-fold higher in F4 than F3 hepatitis C (HCV) patients. M2BPGi was observed to be etiology-specific and HCV patients had higher mean M2BPGi levels. We also observed significant correlations with aspartate aminotransferase to platelet ratio index and fibrosis-4 index as well as HBV DNA levels. Mean M2BPGi levels for HBV patients with a viral load lower than 2000 IU/mL was 1.75-fold lower than those with a viral load greater than 2000 IU/mL.
M2BPGi was observed to be a good indicator of early liver disease in patients with different etiologies. Our results provide reference cut-offs for different causes of liver disease and demonstrated the utility of this marker for early disease monitoring. This is useful for remote regions in developing countries.
Core tip: Mac-2 binding protein glycosylation isomer levels can be used for non-invasive liver fibrosis staging in the Vietnamese population with mixed etiologies. In early evaluations, significantly higher levels of this marker were observed in cirrhotic patients and showed good correlations with viral load testing in hepatitis B. This marker is convenient and useful, especially in resource limited countries for fast turnaround to assess liver disease.