Lyu J, Imachi H, Fukunaga K, Yoshimoto T, Zhang H, Murao K. Roles of lipoprotein receptors in the entry of hepatitis C virus. World J Hepatol 2015; 7(24): 2535-2542 [PMID: 26527170 DOI: 10.4254/wjh.v7.i24.2535]
Corresponding Author of This Article
Koji Murao, MD, PhD, Professor, Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, 1750-1, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. mkoji@med.kagawa-u.ac.jp
Research Domain of This Article
Virology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Takuo Yoshimoto, Koji Murao, Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan
Jingya Lyu, Huanxiang Zhang, Department of Cell Biology, Medical College of Soochow University, Jiangsu Key Laboratory of Stem Cell Research, Suzhou 215123, Jiangsu Province, China
Author contributions: Lyu J contributed to summarize all the points and draft the article; Imachi H, Fukunaga K and Yoshimoto T contributed to collect and interpret the data; Zhang H and Murao K contributed to design of the study and final approval of the version of the article to be published.
Supported by The Ministry of Education, Culture, Sports, Science and Technology to Hitomi Imachi, Koji Murao, Japan, Nos. 24591352, 15K09415; and National Natural Science Foundation of China to Huanxiang Zhang, Nos. 31371407 and 31071220.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Koji Murao, MD, PhD, Professor, Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, 1750-1, Miki-cho, Kita-gun, Kagawa 761-0793, Japan. mkoji@med.kagawa-u.ac.jp
Telephone: +81-878-912230
Received: June 27, 2015 Peer-review started: June 29, 2015 First decision: July 25, 2015 Revised: August 24, 2015 Accepted: September 25, 2015 Article in press: September 28, 2015 Published online: October 28, 2015 Processing time: 124 Days and 22.2 Hours
Abstract
Infection by hepatitis C virus (HCV), a plus-stranded RNA virus that can cause cirrhosis and hepatocellular carcinoma, is one of the major health problems in the world. HCV infection is considered as a multi-step complex process and correlated with abnormal metabolism of lipoprotein. In addition, virus attacks hepatocytes by the initial attaching viral envelop glycoprotein E1/E2 to receptors of lipoproteins on host cells. With the development of HCV model system, mechanisms of HCV cell entry through lipoprotein uptake and its receptor have been extensively studied in detail. Here we summarize recent knowledge about the role of lipoprotein receptors, scavenger receptor class B type I and low-density lipoprotein receptor in the entry of HCV, providing a foundation of novel targeting therapeutic tools against HCV infection.
Core tip: As cirrhosis and hepatocellular carcinoma caused by hepatitis C virus (HCV) is one of the major health problems in the world, the investigation of HCV infection becomes more and more important. HCV entry is the initial step to start infection and is a multiple process involved in abnormal metabolism of lipid. Hence, here we summarize recent knowledge about the role of lipoprotein receptors for better understanding of HCV.
