Evaluating the RESET care program: Advancing towards scalable and effective healthcare solutions for metabolic dysfunction-associated liver disease

Abstract

In this article, we discuss the recently published article by Soni et al. This study explores the effectiveness of a comprehensive digital health program, RESET care, which integrates personalized dietary plans, structured exercise, and cognitive behavioral therapy delivered through a mobile app equipped with Internet of Things devices such as body composition analyzers and smartwatches. Metabolic dysfunction-associated liver disease (MASLD), a global health burden affecting approximately 25% of the population, demands sustainable lifestyle modifications as its primary management strategy. The study reports that 100% of participants in the comprehensive intervention group (diet + exercise + cognitive behavioral therapy) achieved a weight reduction ≥ 7% (6.99 ± 2.98 kg, 7.00% ± 3.39%; P = 0.002), a clinically significant threshold for MASLD improvement. In addition, participants showed a mean weight reduction of 6.99 kg (101.10 ± 17.85 vs 94.11 ± 17.38, P < 0.001) and a body mass index reduction of 2.18 kg/m² (32.90 ± 3.02 vs 30.72 ± 3.41, P < 0.001). These results underscore the potential of digital health platforms to provide scalable, evidence-based solutions for the treatment of MASLD. While these results highlight the potential of digital platforms in the scalable and personalized management of MASLD, the small study sample size and short duration of follow-up limit the generalizability of the results. Future large-scale, long-term trials are needed to confirm sustained benefits, cost-effectiveness, and broader applicability. This letter contextualizes the study within the evolving landscape of MASLD management and emphasizes the clinical implications of integrating digital technologies into standard care.

Keywords: Steatotic liver disease; Digital health interventions; Diet and exercise regimens; Lifestyle modifications; Metabolic dysfunction-associated liver disease

Core Tip: This article discusses the effectiveness of the RESET care program, a digital health intervention integrating a personalized diet, structured exercise, and cognitive behavioral therapy for managing metabolic dysfunction-associated liver disease. Delivered via a mobile app supported by Internet of Things devices, the program provides real-time, patient-centred monitoring and support. The study demonstrated that participants receiving the full intervention (diet, exercise, and cognitive behavioral therapy) achieved superior weight reduction and anthropometric improvements, meeting the critical 7% weight loss threshold for improving metabolic dysfunction-associated liver disease outcomes. The RESET care program underscores the transformative potential of digital health platforms in providing scalable, effective solutions for chronic disease management.