Soni J, Pathak N, Gharia M, Aswal D, Parikh J, Sharma P, Mishra A, Lalan D, Maheshwari T. Effectiveness of RESET care program: A real-world-evidence on managing non-alcoholic fatty liver disease through digital health interventions. World J Hepatol 2025; 17(1): 101630 [DOI: 10.4254/wjh.v17.i1.101630]
Corresponding Author of This Article
Mihir Gharia, Medical Affairs, Tatvacare, Plot No. 115/5, No. 51 TP Scheme Road, Ahmedabad 380058, Gujarāt, India. mihir10584@gmail.com
Research Domain of This Article
Medicine, General & Internal
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Author contributions: Soni J and Pathak N conducted patient enrollment and data collection; Parikh J and Sharma P wrote, and edited the manuscript; Aswal D and Gharia M supervised the study; Mishra A created the images and graphics; Lalan D and Maheshwari T assisted with data analysis and manuscript revisions.
Institutional review board statement: The study received approval from the ACEAS-Independent Ethics Committee with protocol number: MTNAFLD120324.
Informed consent statement: Upon onboarding to MyTatva app, all participants were informed about the use of the digital health app and associated monitoring tools. They provided consent to participate and agreed to the collection and use of their data for research purposes.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available for this study. The dataset analyzed was fully anonymized, and no further information can be provided beyond the results presented in this manuscript.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mihir Gharia, Medical Affairs, Tatvacare, Plot No. 115/5, No. 51 TP Scheme Road, Ahmedabad 380058, Gujarāt, India. mihir10584@gmail.com
Received: September 23, 2024 Revised: November 11, 2024 Accepted: December 2, 2024 Published online: January 27, 2025 Processing time: 106 Days and 19.9 Hours
Abstract
BACKGROUND
Non-alcoholic fatty liver disease (NAFLD) management requires sustainable lifestyle modifications. This study aimed to evaluate the effectiveness of the RESET care plan, a comprehensive program that is an integrated personalized diet, exercise, and cognitive behavior therapy, delivered via MyTatva’s digital health application enabled through a body composition analyzer (BCA) and smartwatch.
AIM
To evaluates the effectiveness of the comprehensive program delivered via MyTatva’s digital health app enabled through internet of thing devices.
METHODS
This retrospective observational study analyzed deidentified data from 22 participants enrolled in the MyTatva RESET care program. Participants were divided into three groups: Group A, diet plan; Group B, diet + exercise plan; and Group C, diet + exercise + cognitive behavioral therapy plan. Participants were provided with a BCA and smartwatch for continuous monitoring of anthropometric parameters. Statistical analysis, including one-way ANOVA and post-hoc Tukey’s Honest Significant Difference test, was conducted to compare mean changes in anthropometric parameters across the groups.
RESULTS
All intervention groups showed significant improvement across all anthropometric parameters. Group C showed the most significant improvements, with mean weight reduction of 7% or more (6.99 ± 2.98 kg, 7.00% ± 3.39%; P = 0.002) from baseline, a benchmark associated with improved NAFLD conditions. Post-hoc analysis revealed that Group C had significantly greater improvements than Groups A and B. Weight reduction was observed in 85.7% of Group A participants, 77.8% of Group B participants, and 100% of Group C participants.
CONCLUSION
The comprehensive RESET care plan achieved a 7% weight reduction in 12 weeks, demonstrating its effectiveness in managing NAFLD. These results support adopting digitally supported, patient-centric approaches for NAFLD treatment.
Core Tip: This study evaluates the RESET care program, a comprehensive digital health intervention for managing non-alcoholic fatty liver disease (NAFLD). By integrating personalized diet, exercise, and cognitive behavioral therapy (CBT) through a mobile app supported by internet of things devices, the program offers continuous, tailored support for lifestyle modifications crucial to NAFLD management. Results demonstrate that participants receiving all three interventions (diet, exercise, CBT) achieved significant weight reduction and improved health outcomes. The RESET care program highlights the potential of digital tools in delivering accessible, scalable solutions for chronic disease management.
