Published online May 27, 2020. doi: 10.4254/wjh.v12.i5.230
Peer-review started: December 6, 2019
First decision: December 26, 2019
Revised: February 29, 2020
Accepted: April 4, 2020
Article in press: April 4, 2020
Published online: May 27, 2020
Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide.
To describe the epidemiological profile and mortality rates of patients with ALD admitted to public hospitals in different regions of Brazil from 2006 to 2015.
This is a descriptive study that evaluated aggregate data from the five Brazilian geographic regions.
A total of 160093 public hospitalizations for ALD were registered. There was a 34.07% increase in the total number of admissions over 10 years, from 12879 in 2006 to 17267 in 2015. The region with the highest proportion (49.01%) of ALD hospitalizations was Southeast (n = 78463). The North region had the lowest absolute number of patients throughout the study period, corresponding to 3.9% of the total (n = 6242). There was a 24.72% increase in the total number of ALD deaths between 2006 and 2015. We found that the age group between 50 and 59 years had the highest proportion of both hospitalizations and deaths: 28.94% (n = 46329) of total hospital admissions and 29.43% (n = 28864) of all deaths. Men were more frequently hospitalized than women and had the highest proportions of deaths in all regions. Mortality coefficient rates increased over the years, and simple linear regression analysis indicated a statistically significant upward trend in this mortality (R² = 0.744).
Our study provides a landscape of the epidemiological profile of public hospital admissions due to ALD in Brazil. We detected an increase in the total number of admissions and deaths due to ALD over 10 years.
Core tip: Alcoholic liver disease (ALD) is one of the main causes of chronic liver disease worldwide. Many patients with ALD present for medical care after they have developed advanced liver disease and its complications. It is important to know the epidemiology of ALD within a specific region/country to better understand which resources might be necessary to improve management. This study provides a landscape of the epidemiological profile of hospital admissions due to ALD in different regions of Brazil from 2006 to 2015, including the mortality rates and admissions according to age range. We detected a 34.07% increase in the total number of hospital admissions for ALD and a 24.72% increase in the total number of ALD deaths over these 10 years. Therefore, this study signals the need to be alert to this liver illness and to possibly revisit policies related to alcohol marketing, sales, and consumption.