High frequency of CD34+CD38-/low immature leukemia cells is correlated with unfavorable prognosis in acute myeloid leukemia

Table 1 Impact of prognostic factors on disease free survival and overall survival

Prognostic factors	Impact of prognostic factors on overall survival OS (wo palliatives, wo M3), n = 153				Impact of prognostic factors on disease free survival DFS (wo palliatives, wo M3), n = 101
	Univariate analysis P value	Multivariate analysis P value	95%CI	HR	Univariate analysis P value	Multivariate analysis P value	95%CI	HR
Age > 60 yr	P < 0.0001	P = 0.02268	1.15-6.13	2.65	P = 0.21	P = 0.76834	0.33-2.25	0.87
WBC	P = 0.74	P = 0.10429	1-1.02	1.01	P = 0.13	P = 0.00184	1.01-1.02	1.01
Cytogenetic risk subgroup	P < 0.0001
Favorable		P = 0.31675	0.43-13.33	2.4
Intermediate		P = 0.05414	0.97-33.01	5.66
Unfavorable
Molecular anomalies
FLT3ITD-					P = 0.82	P = 0.70619	0.32-5.27	1.31
NMP1-					P = 0.04	P = 0.01139	1.79-98.56	13.29
EVI1-					P = 0.89	P = 0.47958	0.38-8	1.74
%CD34 of Blasts	P = 0.47	P = 0.08765	1-1.03	1.01	P = 0.15	P = 0.95058	0.99-1.02	1
%CD34+CD38- of Blasts > 1%	P = 0.0001	P = 0.03091	1.09-6.43	2.65	P = 0.0005	P = 0.04663	1.02-7.73	2.8

This analysis excluded palliative cases and M3 subtypes. OS: Overall survival; DFS: Disease free survival; WBC: White blood cell.