©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
High frequency of CD34+CD38-/low immature leukemia cells is correlated with unfavorable prognosis in acute myeloid leukemia
Adriana Plesa, Charles Dumontet, Eve Mattei, Sandrine Hayette, Pierre Sujobert, Isabelle Tigaud, Marie Pierre Pages, Laboratory of Hematology, Lyon-Sud Hospital, Hospices Civils de Lyon, Pierre - Bénite Cedex 69495, France
Adriana Plesa, Charles Dumontet, Ines Tagoug, CRCL, INSERM 1052/CNRS 5286, Lyon FR-69008, France
Youcef Chelghoum, Fiorenza Baracco, Helene Labussierre, Sophie Ducastelle, Etienne Paubelle, Franck Emmanuel Nicolini, Mohamed Elhamri, Claudiu Plesa, Gilles Salles, Mauricette Michallet, Xavier Thomas, Department of Hematology, Hospices Civils de Lyon, Pierre - Bénite Cedex 69495, France
Lydia Campos, Laboratory of Hematology, Nord Hospital, Saint Etienne 42055, France
Stéphane Morisset, Statistical and Clinical Research, Lyon-Sud Hospital, Hospices Civils de Lyon, Pierre - Bénite Cedex 69495, France
Yves Bertrand, Department of Pediatric Hematology and BMT, IHOP Lyon, Lyon 69001, France
Author contributions: Plesa A, Dumontet C and Thomas X designed the study, drafted the manuscript and prepared the final version; Chelghoum Y, Baracco F, Labussiere H, Ducastelle S, Paubelle E, Nicolini FE, Plesa C, Salles G, Bertrand Y, Michallet M and Thomas X included patients and collected clinical data; Plesa A, Morisset S and Thomas X performed statistical analysis; Hayette S and Sujobert P performed molecular analyses; Tigaud I and Pages MP performed cytogenetic analyses for all patients; Plesa A collected morphological data; Tagoug I and Elhamri M participated to collecting biological and clinical data; Mattei E participated to collected flowcytometric data; Campos L, Bertrand Y, Michallet M and Salles G revised the final version; all authors approved the final version of the manuscript.
Institutional review board statement: Lyon University Hospital-Hematology Review Board.
Informed consent statement: All clinical trials have been reviewed and approved by a relevant ethic committee and were performed in accordance with the Helsinki declaration of 1975. All patients gave informed consent according to French legislation.
Conflict-of-interest statement: None of the authors have anything to disclose regarding this study.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Adriana Plesa, MD, Laboratory of Hematology, Lyon-Sud Hospital, Hospices Civils de Lyon, 165, Chemin du Grand Revoyet, Pierre - Bénite Cedex 69495, France. email@example.com
Received: January 29, 2017
Peer-review started: February 13, 2017
First decision: May 10, 2017
Revised: October 17, 2017
Accepted: November 8, 2017
Article in press: November 8, 2017
Published online: December 26, 2017