Ovarian stem cells: From basic to clinical applications

Table 1 Articles in the field of ovarian germline stem cells and oogenesis

Ref.	Main findings
Johnson et al[1]	Ovarian GSCs are observed within the ovarian surface epithelium and provide the adult mouse ovary with oocytes
Johnson et al[25]	GSCs are detected in mouse bone marrow and provide the postnatal mouse ovary with oocytes
Kerr et al[14]	The follicle numbers remain constant in ovaries of juvenile and early adult mice. Follicle renewal in postnatal and adult mouse ovaries is suggested
Zou et al[29]	Mouse ovarian GCS are isolated by immunoselection and characterized. Ovarian GCSs transplanted into ovaries of infertile mice undergo oogenesis and produce offspring
Pacchiarotti et al[30]	The adult mouse ovarian GSCs are isolated by FACS. Long-term expanded mouse ovarian GSCs maintain their characteristics, telomerase activity and express germ cell and stem cell markers
White et al[7]	The ovarian GSCs are isolated by FACS. Xenotransplantation of human GCSs into NOD-SCID mice leads to the formation of follicles containing oocytes
Zhang et al[32]	No mitotically active female GSCs exist in postnatal mouse ovaries
Lei et al[33]	The adult female mouse ovary does not contain active ovarian GSCs. The number of follicles produced during fetal development is sufficient to provide ovaries with oocytes in adult life
Park et al[39]	Existence of mitotically active germ cells in the postnatal mouse ovary demonstrated by a genetic approach coupled with a GSCs selection strategy

GSCs: Germline stem cells; FACS: Fluorescence-activated cell sorting.

Table 2 Markers of ovarian cancer stem cells

Marker	Ref.
Side population	Szotek et al[9]
CD44/CD117	Zhang et al[10]
Natriureticpeptide receptor A	Kong et al[11]
CD133	Ferradina et al[45]
CD24	Gao et al[13]
DEAD box polypeptide 4	Hashimoto et al[12]

DEAD: Asp-Glu-Ala-Asp.