Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2015; 7(4): 757-768
Published online May 26, 2015. doi: 10.4252/wjsc.v7.i4.757
Ovarian stem cells: From basic to clinical applications
Ozlem Bingol Ozakpinar, Anne-Marie Maurer, Derya Ozsavci
Ozlem Bingol Ozakpinar, Derya Ozsavci, Department of Biochemistry, School of Pharmacy, Marmara University, 34668 Istanbul, Turkey
Anne-Marie Maurer, Department of Hematology, School of Medicine, Marmara University, Pendik, 34668 Istanbul, Turkey
Author contributions: All the authors contributed equally to the writing of this manuscript.
Conflict-of-interest: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Ozlem Bingol Ozakpinar, PhD, Department of Biochemistry, School of Pharmacy, Marmara University, Tıbbiye Cad. No:49 Haydarpaşa, 34668 Istanbul, Turkey.
Telephone: +90-216-4142962 Fax: +90-216-3452952
Received: July 29, 2014
Peer-review started: July 29, 2014
First decision: November 27, 2014
Revised: January 28, 2015
Accepted: March 16, 2015
Article in press: March 18, 2015
Published online: May 26, 2015
Core Tip

Core tip: This review provides an overview on postnatal ovarian germinal stem cells (GSC) of mammals. The characteristics of these cells and the last developments in the field of oogenesis have been presented. We also discuss the relationship between ovarian GSCs and ovarian cancer stem cells. The identification and characterization of these two types of cells are essential for a better understanding of tumor initiation, progression and treatment.