Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts

doi:10.4252/wjsc.v5.i4.136

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Oct 26, 2013; 5(4): 136-148
Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.136

Table 1 Non-exhaustive list of miRs that have been reported to inhibit or stimulate osteoblast differentiation in mouse or human

miR	Species	Target	Effect	Ref.
MiR-206	Mouse	Connexin 43	Inhibitory	[129]
MiR-34	Mouse	Satb 2	Inhibitory	[130]
MiR-27a	Human	TNAP	Inhibitory	[131]
MiR-204	Mouse	Runx 2	Inhibitory	[132]
MiR-204/211	Human	Runx 2	Inhibitory	[143]
MiR-133	Mouse	Runx 2	Inhibitory	[133]
MiR-135	Mouse	Smad 5	Inhibitory	[133]
MiR-433	Mouse	Runx 2	Inhibitory	[134]
MiR-335	Human	Runx 2	Inhibitory	[142]
MiR-138	Human	FAK	Inhibitory	[144]
MiR-2861	Mouse	HDAC 5	Stimulatory	[136]
MiR-335-5p	Mouse	Dkk 1	Stimulatory	[137]
MiR-29a	Human	Dkk 1, Kremen 2	Stimulatory	[138]

MiRs: MicroRNAs; FAK: Focal adhesion kinase; HDAC 5: Histone deacetylase 5; TNAP: Tissue-nonspecific alkaline phosphatase; Dkk 1: Dickkopf-related protein 1; Runx 2: Runt-related 2; Satb2: Special AT-rich sequence binding protein 2; Smad5: Portmanteau of Sma in Drosophila and Mad in C. elegans.

Citation: Fakhry M, Hamade E, Badran B, Buchet R, Magne D. Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts. World J Stem Cells 2013; 5(4): 136-148
URL: https://www.wjgnet.com/1948-0210/full/v5/i4/136.htm
DOI: https://dx.doi.org/10.4252/wjsc.v5.i4.136