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World J Stem Cells. Oct 26, 2013; 5(4): 136-148
Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.136
Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.136
Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts
Maya Fakhry, René Buchet, David Magne, ICBMS, UMR CNRS 5246, University of Lyon 1, 69622 Villeurbanne Cedex, France
Maya Fakhry, Eva Hamade, Bassam Badran, Genomic and Health laboratory/PRASE-EDST Campus Rafic Hariri-Hadath-Beirut-Liban, Faculty of Sciences, Lebanese university, Beirut 999095, Lebanon
Author contributions: Magne D wrote most of the article; Fakhry M wrote the part on microRNAs; Hamade E, Badran B and Buchet R critically revised the article, and significantly improved it.
Correspondence to: David Magne, PhD, ICBMS, UMR CNRS 5246, University of Lyon 1, Bâtiment Raulin, 43 Bd du 11 novembre 1918, 69622 Villeurbanne Cedex, France. david.magne@univ-lyon1.fr
Telephone: +33-4-27465720 Fax: +33-4-72431543
Received: June 24, 2013
Revised: August 30, 2013
Accepted: September 14, 2013
Published online: October 26, 2013
Processing time: 128 Days and 18.8 Hours
Revised: August 30, 2013
Accepted: September 14, 2013
Published online: October 26, 2013
Processing time: 128 Days and 18.8 Hours
Core Tip
Core tip: Several excellent reviews on the transcription factors involved in osteoblast differentiation have recently been published, but none also presented the microRNAs (miRs) that control the expression of these transcription factors. Moreover, most of these reviews mainly reported mouse studies but important differences are well acknowledged between humans and mice. For instance vitamin D3, an important hormone controlling bone homeostasis, has very different effect in these species. Therefore, in the present review we particularly focus on human cells to present the transcription factors and miRs controlling mesenchymal stem cells-osteoblastic differentiation.