First-ever stem cell therapy restores insulin independence in type 1 diabetes: A medical milestone

doi:10.4252/wjsc.v17.i7.106856

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Jul 26, 2025 (publication date) through Jul 27, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jul 26, 2025; 17(7): 106856
Published online Jul 26, 2025. doi: 10.4252/wjsc.v17.i7.106856

Table 1 Clinical trials for stem cell-based therapies of type 1 diabetes

Trial ID	Cell type	Phase/status	Key feature
ChiCTR2300072200	iPSC (autologous)	Approved	Personalized therapy in T1D
NCT04061746	MSC (umbilical cord)	Recruiting	Immune modulation
NCT03163511	ESC-derived beta cells	Active	Subcutaneous VC-02 implant
NCT03920397	MSC + Vit D	Recruiting	Combination strategy
NCT04817774	CAR-T Reg	Not completed	Regulatory cell targeting
NCT02239354	hESCs (VC-01)	Suspended	Safety issues noted

iPSC: Induced pluripotent stem cell; T1D: Type 1 diabetes; MSC: Mesenchymal stem cell; ESC: Embryonic stem cell; Vit D: Vitamin D; CAR-T: Chimeric antigen receptor-modified T cell; Reg: Regulatory; hESCs: Human embryonic stem cell.

Citation: Kumar D, Tanwar R, Gupta V. First-ever stem cell therapy restores insulin independence in type 1 diabetes: A medical milestone. World J Stem Cells 2025; 17(7): 106856
URL: https://www.wjgnet.com/1948-0210/full/v17/i7/106856.htm
DOI: https://dx.doi.org/10.4252/wjsc.v17.i7.106856