Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jul 26, 2025; 17(7): 106856
Published online Jul 26, 2025. doi: 10.4252/wjsc.v17.i7.106856
First-ever stem cell therapy restores insulin independence in type 1 diabetes: A medical milestone
Dinesh Kumar, Rajni Tanwar, Vrinda Gupta
Dinesh Kumar, Rajni Tanwar, Vrinda Gupta, School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh 147301, Punjab, India
Author contributions: Kumar D, Tanwar R, and Gupta V contributed equally to the drafting and writing of the manuscript. Kumar D conceptualized the study and prepared the main draft; Tanwar R handled literature referencing and data analysis; Gupta V contributed to writing and revisions.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dinesh Kumar, Associate Professor, School of Pharmacy, Desh Bhagat University, Amloh Road, Mandi Gobindgarh 147301, Punjab, India. dineshpotlia123@gmail.com
Received: March 11, 2025
Revised: May 14, 2025
Accepted: June 23, 2025
Published online: July 26, 2025
Processing time: 137 Days and 17 Hours
Core Tip

Core Tip: Stem cell therapy is emerging as a promising approach for type 1 diabetes by regenerating insulin-producing beta cells. This article highlights the first reported case of insulin independence using autologous induced pluripotent stem cell-derived islet-like cells and critically discusses clinical trial trends, ethical concerns, and safety considerations. While not yet a cure, these developments offer a glimpse into the future of regenerative diabetes therapy.