L-arginine from elder human mesenchymal stem cells induces angiogenesis and enhances therapeutic effects on ischemic heart diseases

Table 1 Clinical characteristics of the adiposederived stem cells and bone marrow stem cells donors

Indicator	Value (n = 40)
Gender
Male	31 (77.5)
Female	9 (22.5)
Age (years)	68 ± 6.9
BMI (kg/m2)	24 ± 2.1
Concomitant metabolic disorders	No

Data are presented as n (%). BMI: Body mass index.

Table 2 Detailed information for 42 potential adipose tissue-derived mesenchymal stem cell and bone marrow-derived mesenchymal stem cell biomarkers

Num	Name	m/z	Rt(s)	P value	VIP
Positive mode (ESI+)
P1	Chlorate	106.95	46.69	0.01211	1.18
P2	Dimethyl carbonate	113.02	65.77	0.00001	2.13
P3	2-acetylpyrazine	123.05	62.40	0.00786	1.13
P4	L-cyclo(alanylglycyl)	129.07	55.49	0.00850	1.19
P5	Pyrroline hydroxycarboxylic acid	130.05	371.82	0.02397	1.11
P6	3-furoic acid	135.00	64.98	0.00144	1.27
P7	(3S)-3,6-diaminohexanoate	147.11	44.84	0.02305	1.14
P8	L-4-hydroxyglutamate semialdehyde	148.06	371.82	0.02329	1.12
P9	Methyl 2-propenyl selenide	158.97	46.80	0.02157	1.17
P10	3-oxoadipic acid	161.05	426.39	0.00225	1.20
P11	1-(2-furanylmethyl)-1H-pyrrole	170.05	56.27	0.00071	1.28
P12	L-arginine	175.12	54.32	0.04341	1.01
P13	3,5-dihydroxybenzoic acid	177.02	48.78	0.00178	1.17
P14	L-2,3-dihydrodipicolinate	192.03	58.70	0.01307	1.07
P15	Alpha-D-glucose	203.05	53.34	0.01773	1.40
P16	1-aminopyrene	218.10	65.96	0.00001	2.88
P17	Isovalerylglutamic acid	232.12	80.44	0.00053	1.59
P18	Cysteinyl-gamma-glutamate	250.08	367.38	0.00030	1.45
P19	Threoninyl-gamma-glutamate	270.11	422.74	0.00134	1.70
P20	Pyruvic acid	272.12	440.40	0.00153	1.75
P21	3-oxooctanoic acid glycerides	272.12	440.40	0.00153	1.75
P22	Thymidine 3’,5’-cyclic monophosphate	305.05	437.12	0.00062	1.65
P23	Rhazidigenine Nb-oxide	337.19	524.49	0.00155	1.49
P24	5-megastigmen-7-yne-3,9-diol 3-glucoside	371.20	478.05	0.00134	1.59
P25	Aurantiumal	377.13	401.34	0.00000	3.58
P26	Gibberellin A59	383.11	53.34	0.00011	1.54
P27	Dukunolide E	507.15	470.89	0.00000	3.03
P28	Janthitrem E	604.35	424.91	0.00081	1.92
P29	Notoginsenoside T1	653.44	913.54	0.00174	2.31
P30	Spirolide D	708.49	724.88	0.00184	1.75
P31	PE(15:0/20:2(11Z,14Z))	752.51	722.06	0.00158	1.78
P32	L-citramalyl-CoA	920.14	54.81	0.04634	1.18
Negative mode (ESI-)
N1	3-oxoadipic acid	159.03	65.65	0.00009	1.45
N2	5-hydroxyindoleacetaldehyde	174.06	470.87	0.00010	1.96
N3	Suberenone	243.07	68.86	0.00000	2.64
N4	Pseudouridine	243.07	68.86	0.00000	2.64
N5	4’-o-methylkanzonol W	349.10	64.34	0.00006	2.05
N6	DIMBOA-Glc	372.10	68.31	0.00010	2.41
N7	Melleolide D	481.16	68.85	0.00000	2.63

ESI: Electron spray ionization.