L-arginine from elder human mesenchymal stem cells induces angiogenesis and enhances therapeutic effects on ischemic heart diseases

doi:10.4252/wjsc.v17.i4.103314

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Apr 26, 2025; 17(4): 103314
Published online Apr 26, 2025. doi: 10.4252/wjsc.v17.i4.103314

L-arginine from elder human mesenchymal stem cells induces angiogenesis and enhances therapeutic effects on ischemic heart diseases

Jian-Zhong Li, Xu Zhan, Hao-Bo Sun, Chao Chi, Guo-Fu Zhang, Dong-Hui Liu, Wen-Xi Zhang, Li-Hua Sun, Kai Kang

Jian-Zhong Li, Xu Zhan, Hao-Bo Sun, Chao Chi, Guo-Fu Zhang, Dong-Hui Liu, Wen-Xi Zhang, Kai Kang, Department of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China

Jian-Zhong Li, Xu Zhan, Hao-Bo Sun, Kai Kang, Key Laboratory of Cell Transplantation of the National Ministry of Public Health, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China

Jian-Zhong Li, Department of Thoracic Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710014, Shaanxi Province, China

Li-Hua Sun, Department of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University and Pharmacology Department of Pharmacy College of Harbin Medical University, Harbin Medical University, Harbin 150081, Heilongjiang Province, China

Kai Kang, Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin 150001, Heilongjiang Province, China

Co-first authors: Jian-Zhong Li and Xu Zhan.

Co-corresponding authors: Li-Hua Sun and Kai Kang.

Author contributions: Li JZ and Zhan X contributed equally to this manuscript as co-first authors. Li JZ, Zhan X, and Sun HB performed the research and participated in data processing and statistical analyses; Chi C, Zhang GF, Liu DH, and Zhang WX provided experimental technical support; Li JZ, Sun LH, and Kang K wrote the manuscript and contributed to conception of the research project. Sun LH and Kang K contributed equally to this manuscript as co-corresponding authors.

Supported by the National Natural Science Foundation of China, No. 82472147; the Key Research and Development Program of Heilongjiang Province of China, No. 2023ZX06C04; and the Open Fund of Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, China, No. GPKF202402.

Institutional review board statement: All human subject protocols were reviewed and approved by the Ethics Committee of the Second Affiliated Hospital of Harbin Medical University (Ethics No. 2014-R-010) and informed consent was obtained from each patient.

Institutional animal care and use committee statement: The animal experiments were conducted in accordance with the guidelines of the Institutional Animal Care and Use Committee of the Second Affiliated Hospital of Harbin Medical University, approval number 2015013.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.

Data sharing statement: sharing statement: All data generated or analyzed during this study are included in this published article and its supplementary information file.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Kai Kang, Department of Cardiovascular Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Road, Harbin 150001, Heilongjiang Province, China. kangkai1975@sina.com

Received: November 15, 2024
Revised: February 6, 2025
Accepted: March 17, 2025
Published online: April 26, 2025
Processing time: 159 Days and 12.5 Hours

Core Tip

Core Tip: Adipose tissue-derived mesenchymal stem cells exhibited the advantages of angiogenesis compared to bone marrow-derived mesenchymal stem cells from elderly donors due to higher L-arginine secretion in serum-free and hypoxic conditions. In an animal model of MI, bone marrow-derived mesenchymal stem cells in which the arginine succinate lyase gene was integrated had a cardioprotective effect on angiogenesis. These results indicated that adipose tissue-derived mesenchymal stem cells from elderly patients with coronary heart disease and the introduction of L-arginine provide a promising strategy for stem cell therapy after MI.