Copyright ©The Author(s) 2023.
World J Stem Cells. May 26, 2023; 15(5): 354-368
Published online May 26, 2023. doi: 10.4252/wjsc.v15.i5.354
Table 1 Apoptosis regulation of intestinal stem cells
Biological process or signaling
Mitochondrial dysfunctionPumaPro-apoptoticPuma depletion reduces chemoradiotherapy- induced apoptosis in a p53-dependent manner[102,136]
Bcl-2Anti-apoptoticBcl-2 is highly expressed in ISCs and alleviating radiation-induced damage[137]
SurvivinAnti-apoptoticAn essential guardian of ISC during mucosal healing[138]
PRPS1Pro-apoptoticPRPS1 deficiency exhibit resistance against intestinal damage in a manner dependent upon Lgr5+ ISCs[139]
Immune responseIL-22Anti-apoptoticIL-22 deficiency led to increased crypt apoptosis, depletion of ISCs[97]
NOD2Anti-apoptoticNod2 stimulation triggers stem cell survival against oxidative stress-mediated cell death[93]
HippoYAPAnti-apoptoticLoss of YAP activity results in sensitivity of crypt stem cells to apoptosis and reduced cell proliferation during regeneration[140]
GPCRβ-Arrestin1/2Anti-apoptoticβArr reduced the chemotherapy- induced Lgr5+ stem cell apoptosis by inhibiting endoplasmic reticulum stress[141,142]
HormoneGLP-2Anti-apoptoticGLP-2 expanded intestinal organoids and downregulated apoptosis-related genes[143]
GhrelinAnti-apoptoticGhrelin treatment accelerated the reversal of radiation-induced epithelial damage and defective self-renewing property of ISCs[144]
MethylationMettl14Anti-apoptoticSpecific deletion of the Mettl14 gene resulted in colonic stem cell apoptosis[145]
GsdmCAnti-apoptoticGsdmC N6-adenomethylation protects mitochondrial homeostasis and is essential for Lgr5+ cell survival[146]
GlycosylationHYOU1Anti-apoptoticHYOU1 glycosylation modulated by FUT2 protects ISCs against apoptosis[147]