SOX transcription factors and glioma stem cells: Choosing between stemness and differentiation

Table 1 Classification of the human SOX genes[35]

SOXA	SOXB		SOXC	SOXD	SOXE	SOXF	SOXG	SOXH
	SOXB1	SOXB2
SRY	SOX1	SOX14	SOX4	SOX5	SOX8	SOX7	SOX15	SOX30
	SOX2	SOX21	SOX11	SOX6	SOX9	SOX17
	SOX3		SOX12	SOX13	SOX10	SOX18

Table 2 SOX gene activity in glioblastoma and correlation with the clinical outcome of glioblastoma patients

Ref.	Gene	Activity	Clinical outcome
[94]	SOX1	Oncogenic	Poor
[98-101]	SOX2	Oncogenic	Poor
[104,105]	SOX3	Possible oncogenic	No correlation /poor
[129-131]	SOX4	Oncogenic in glioma-initiating cells; tumor suppressor in GBM	Poor/good
[115,125]	SOX5	Tumor suppressor	Poor
[116,125]	SOX6	Tumor suppressor	Poor
[117,127]	SOX7	Tumor suppressor; glioma angiogenesis	Poor
[106-108]	SOX9	Oncogenic	Poor
[110,111]	SOX10	Possible oncogenic	Poor
[119]	SOX11	Tumor suppressor	Good

Glioblastoma: GBM.