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©The Author(s) 2020.
World J Stem Cells. Jun 26, 2020; 12(6): 514-526
Published online Jun 26, 2020. doi: 10.4252/wjsc.v12.i6.514
Published online Jun 26, 2020. doi: 10.4252/wjsc.v12.i6.514
Table 1 Patient demographic data
Patients | n = 125 |
Age, yr | 58.3 ± 6.8 |
Sex, female/male | 95 (76%)/30 (24%) |
Lesion size, cm2 | 6.9 ± 2 |
HKA angle, degree | 7.6 ± 2.4 |
Trochlear lesion | |
With lesion | 73 |
Without lesion | 52 |
Second look arthroscopic findings | |
ICRS grade I | 73 |
ICRS grade II | 37 |
ICRS grade III | 15 |
Table 2 Clinical outcomes according to the International Cartilage Repair Society grading system
ICRS grade I (n = 73) | ICRS grade II (n = 37) | ICRS grade III (n = 15) | P value1 | Post hoc5 | |
IKDC | |||||
Preoperative | 28.4 ± 7.4 | 30.1 ± 7.2 | 29.2 ± 8.1 | 0.610 | |
1 yr | 59.3 ± 8.7 | 52.4 ± 10.7 | 54.8 ± 7.1 | 0.005 | I > II = III,I = III |
2 yr | 64.3 ± 9.2 | 58.6 ± 11.1 | 55.0 ± 8.0 | < 0.001 | I > II = III |
3 yr | 68.1 ± 10.8 | 61.0 ± 11.3 | 59.3 ± 5.8 | < 0.001 | I > II = III |
P value2 | < 0.001 | < 0.001 | 0.001 | ||
P value3 | < 0.001 | < 0.001 | 0.842 | ||
P value4 | 0.001 | 0.063 | 0.047 | ||
WOMAC | |||||
Preoperative | 45.1 ± 11 | 41.9 ± 9.2 | 44.3 ± 12.2 | 0.275 | |
1 yr | 11.0 ± 6.9 | 16.8 ± 8.5 | 17.6 ± 5.1 | < 0.001 | I > II = III |
2 yr | 8.4 ± 6.0 | 13.4 ± 8.2 | 17.3 ± 7.4 | < 0.001 | I > II = III |
3 yr | 6.5 ± 6.0 | 10.5 ± 5.6 | 12.6 ± 8.3 | < 0.001 | I > II = III |
P value2 | < 0.001 | < 0.001 | 0.001 | ||
P value3 | < 0.001 | 0.001 | 0.607 | ||
P value4 | 0.003 | 0.002 | 0.018 | ||
VAS | |||||
Preoperative | 7.6 ± 1.4 | 7.5 ± 1.1 | 7.7 ± 0.8 | 0.817 | |
1 yr | 2.1 ± 1.7 | 3.0 ± 1.6 | 3.3 ± 1.2 | 0.002 | I > II = III |
2 yr | 1.5 ± 1.4 | 2.7 ± 1.8 | 3.1 ± 1.2 | < 0.001 | I > II = III |
3 yr | 1.1 ± 1.5 | 2.0 ± 1.4 | 2.6 ± 0.9 | < 0.001 | I > II = III |
P value2 | < 0.001 | < 0.001 | 0.001 | ||
P value3 | < 0.001 | 0.229 | 0.658 | ||
P value4 | 0.004 | 0.019 | 0.103 |
Table 3 Clinical outcomes according to trochlear lesion
Trochlear lesion (n = 73) | No trochlear lesion (n = 52) | P value1 | |
IKDC | |||
Preoperative | 29.3 ± 7.3 | 28.5 ± 7.6 | 0.794 |
1 yr | 56.7 ± 9.7 | 56.7 ± 9.7 | 0.960 |
2 yr | 61.6 ± 10.7 | 61.4 ± 9.5 | 0.916 |
3 yr | 64.7 ± 11 | 65.3 ± 11.4 | 0.493 |
WOMAC | |||
Preoperative | 44.8 ± 10.3 | 43.1 ± 11.1 | 0.288 |
1 yr | 13.8 ± 7.5 | 13.2 ± 8.2 | 0.471 |
2 yr | 10.7 ± 6.9 | 11.3 ± 8.5 | 0.958 |
3 yr | 8.4 ± 6.4 | 8.4 ± 6.8 | 0.755 |
VAS | |||
Preoperative | 7.8 ± 1.2 | 7.3 ± 1.3 | 0.046 |
1 yr | 2.6 ± 1.7 | 2.3 ± 1.6 | 0.331 |
2 yr | 2.1 ± 1.5 | 2.0 ± 1.7 | 0.555 |
3 yr | 1.6 ± 1.4 | 1.4 ± 1.6 | 0.203 |
Table 4 Effect of age and lesion size on clinical outcomes
Age (n = 125) | Lesion size (n = 125) | |||||||
β | t | R2 | P value1 | β | t | R2 | P value1 | |
IKDC | ||||||||
Pre-op | -0.128 | -1.429 | 0.016 | 0.156 | -0.148 | -1.661 | 0.022 | 0.099 |
1 yr | -0.095 | -1.053 | 0.009 | 0.294 | -0.025 | -0.282 | 0.001 | 0.779 |
2 yr | -0.053 | -0.593 | 0.003 | 0.554 | -0.120 | -1.339 | 0.014 | 0.183 |
3 yr | 0.049 | 0.549 | 0.002 | 0.584 | 0.024 | 0.266 | 0.001 | 0.791 |
WOMAC | ||||||||
Pre-op | 0.327 | 3.831 | 0.107 | < 0.001 | 0.305 | 3.550 | 0.093 | 0.001 |
1 yr | 0.173 | 1.945 | 0.030 | 0.054 | 0.040 | 0.440 | 0.002 | 0.661 |
2 yr | -0.005 | -0.055 | < 0.001 | 0.956 | 0.052 | 0.575 | 0.003 | 0.566 |
3 yr | -0.048 | -0.532 | 0.002 | 0.595 | -0.064 | -0.716 | 0.004 | 0.475 |
VAS | ||||||||
Pre-op | 0.115 | 1.286 | 0.013 | 0.201 | 0.335 | 3.943 | 0.112 | < 0.001 |
1 yr | 0.114 | 1.278 | 0.013 | 0.204 | 0.113 | 1.266 | 0.013 | 0.208 |
2 yr | 0.001 | 0.013 | <0.001 | 0.989 | 0.112 | 1.249 | 0.013 | 0.214 |
3 yr | -0.047 | -0.519 | 0.002 | 0.605 | 0.164 | 1.842 | 0.027 | 0.068 |
- Citation: Song JS, Hong KT, Kong CG, Kim NM, Jung JY, Park HS, Kim YJ, Chang KB, Kim SJ. High tibial osteotomy with human umbilical cord blood-derived mesenchymal stem cells implantation for knee cartilage regeneration. World J Stem Cells 2020; 12(6): 514-526
- URL: https://www.wjgnet.com/1948-0210/full/v12/i6/514.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v12.i6.514