Review
Copyright ©The Author(s) 2020.
World J Stem Cells. Dec 26, 2020; 12(12): 1492-1510
Published online Dec 26, 2020. doi: 10.4252/wjsc.v12.i12.1492
Table 1 Noninvasive in vivo imaging of mesenchymal stem cells in treatment and drug delivery for cancer
ImagingImaging modalityLabelingmethod/agentCell typeNaïve/modifiedCell originSubjectRoute of injectionDurationTumorOutcomeClinical translationRef.
OpticalFluorescentFNPsBM-MSCsAlPcS4@FNPs@MSCsHumanMiceIntratumorImmediatelyHuman osteosarcoma Inhibition of tumor Limited Lenna et al[81]
EGFPBM-MSCsTRAIL-MSCsMouseMice Intravenous1-10 dMouse colon cancer Inhibition of tumorLimitedZhang et al[82]
VivoTrack 680BM-MSCsMSCsHumanMice Intravenous2-24 hBreast cancer Inhibition of tumor metastasisLimitedCamorani et al[83]
BioluminescentRlucUC-MSCsHSV-ttk-MSCsHumanMiceIntratumor1-4 dBreast cancer Inhibition of tumorLimitedLeng et al[84]
FlucBM-MSCsMSC-Tet-TK/ MSC-TKMouseMiceIntratumor1 and 5 dMouse colon cancer Inhibition of tumorLimitedKalimuthu et al[85]
FlucBM-MSCsMSC-CXCR4MouseMice Intravenous1 and 24 hBreast cancer Homing of genetically modified MSCs to tumorLimitedKalimuthu et al[86]
FlucBM-MSCsNaïveHumanMice Intravenous5 to 8 wkBreast cancer Homing of MSCs to lung metastatic tumorLimitedMeleshina et al[87]
FlucBM-MSCsNaïveHumanMice Intravenous1 and 24 hThyroid and breast cancer In vitro Dox delivery/homing of MSCs to tumorLimitedKalimuthu et al[88]
FlucBM-MSCsNaïveMouseMice Intravenous1-11 dMurine breast cancer Homing and differentiation of MSCs to tumorLimitedWang et al[89]
FlucBM-MSCsMSCs-oncolytic adenovirusHumanMiceIntravenous15 min to 10 dMurine large cell lung carcinoma Homing of MSCs to tumorLimitedHakkarainen et al[90]
RlucBM-MSCsMSC-e23sFv-Fdt-tBidMouseMiceIntravenous24 hBreast cancer and gastric cancerInhibition of tumorLimited Cai et al[91]
Nuclear PET[18F]-FHBGBM-MSCsMSC-HSV1-TKHumanMiceSubcutaneous4 wkMurine colon carcinoma MSCs stably stay in tumorYesHung et al[60]
124IBM-MSCsMSC-hNISHumanMiceIntravenous72 hHuman hepatocellular carcinomaInhibition of tumorYesKnoop et al[92]
124IBM-MSCsMSC-hNISMouse MiceIntravenous72 hMouse pancreatic tumorInhibition of tumorYesSchug et al[93]
γ-camera123IBM-MSCsMSC-hNISHumanMiceIntravenous72 hHuman hepatocellular carcinomaInhibition of tumorYesKnoop et al[92]
123IBM-MSCsHSP70B-NIS-MSCHumanMiceIntravenous0-72 hHuman hepatocellular carcinomaInhibition of tumorYesTutter et al[94]
123IBM-MSCsMSC-hNISMouse MiceIntravenous72 hMouse pancreatic tumorInhibition of tumorYesSchug et al[93]
123IBM-MSCsMSC-hNISHumanMiceIntravenous72 hHuman hepatocellular carcinomaInhibition of tumorYesSchug et al[95]
99mTcBM-MSCsMSC-hNISHumanMiceIntravenous3-14 dBreast cancer Inhibition of tumorYesDwyer et al[64]
99mTcBM-MSCsMSC-hNISHumanMiceIntravenous3-24 dHuman cervical cancerInhibition of tumorYesBelmar-Lopez et al[96]
MR MRISPIOBM-MSCsMSC-hNISHumanMiceIntravenous3-24 dHuman cervical cancerInhibition of tumorYesBelmar-Lopez et al[96]
SPIO@Au-NPsBM-MSCsMSCHumanMiceIntravenous0-72 hHuman glioma Homing of MSC to tumorYesQiao et al[97]