Review
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Dec 26, 2020; 12(12): 1492-1510
Published online Dec 26, 2020. doi: 10.4252/wjsc.v12.i12.1492
Noninvasive in vivo cell tracking using molecular imaging: A useful tool for developing mesenchymal stem cell-based cancer treatment
Ramya Lakshmi Rajendran, Manasi Pandurang Jogalekar, Prakash Gangadaran, Byeong-Cheol Ahn
Ramya Lakshmi Rajendran, Department of Nuclear Medicine, Kyungpook National University, Daegu 41944, South Korea
Manasi Pandurang Jogalekar, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, United States
Prakash Gangadaran, Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, South Korea
Prakash Gangadaran, Byeong-Cheol Ahn, BK21 Plus KNU Biomedical Convergence Program, Department of Biomedical Science, School of Medicine, Kyungpook National University, Daegu 41944, South Korea
Byeong-Cheol Ahn, Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu 41944, South Korea
Author contributions: Rajendran RL and Jogalekar MP contributed equally to this work; Rajendran RL, Jogalekar MP, Gangadaran P and Ahn BC contributed to the conception, writing, and discussion of this review manuscript; Rajendran RL and Jogalekar MP wrote the initial draft of the manuscript; Gangadaran P and Ahn BC are co-corresponding authors; all authors have read and agreed to the published version of the manuscript.
Supported by Basic Science Research Program via the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Republic of South Korea, No. NRF-2019R1I1A1A01061296 and No. NRF-2019R1I1A3A01063308.
Conflict-of-interest statement: The authors declare that the research was performed in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Byeong-Cheol Ahn, MD, PhD, Professor, Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, 680 gukchaebosang-ro, Jung-gu, Daegu 41944, South Korea. abc2000@knu.ac.kr
Received: June 29, 2020
Peer-review started: June 29, 2020
First decision: September 24, 2020
Revised: October 5, 2020
Accepted: October 21, 2020
Article in press: October 21, 2020
Published online: December 26, 2020
Processing time: 180 Days and 22.6 Hours
Core Tip

Core Tip: There is substantial evidence of the potential of cell therapies in treating various diseases including cancers. Molecular imaging has been actively used for decades to assess cellular processes, evaluate the properties of certain drugs, screen compound libraries, and visualize the fate of cells. This review aimed to confirm whether noninvasive in vivo cell tracking in combination with molecular imaging could be used as a tool for the development of mesenchymal stem cell-based cancer treatment. To that end, the following aspects are outlined in the text: labeling approaches, imaging modalities, advantages and disadvantages of each strategy, and scope and limitations of the various imaging approaches. In conclusion, together with long-term monitoring, a lot can be learned with regard to the hidden potential of MSCs as well as their variable fate in humans.