Copyright
©The Author(s) 2021.
World J Stem Cells. Jan 26, 2021; 13(1): 30-48
Published online Jan 26, 2021. doi: 10.4252/wjsc.v13.i1.30
Published online Jan 26, 2021. doi: 10.4252/wjsc.v13.i1.30
Figure 2 Schematic representation of the adipocyte-to-myofibroblast transition process.
In a pro-fibrotic microenvironment, both mature adipocytes de-differentiated into preadipocytes and undifferentiated adipose-derived stem cells (ADSCs) can give rise to pro-fibrotic myofibroblasts through adipocyte-to-myofibroblast transition. ADSCs: Adipose-derived stem cells; AMT: Adipocyte-to-myofibroblast transition; α-SMA: α-Smooth muscle actin; ECM: Extracellular matrix.
- Citation: Rosa I, Romano E, Fioretto BS, Matucci-Cerinic M, Manetti M. Adipose-derived stem cells: Pathophysiologic implications vs therapeutic potential in systemic sclerosis. World J Stem Cells 2021; 13(1): 30-48
- URL: https://www.wjgnet.com/1948-0210/full/v13/i1/30.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v13.i1.30