Adipose-derived stem cells: Pathophysiologic implications vs therapeutic potential in systemic sclerosis

doi:10.4252/wjsc.v13.i1.30

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Jan 26, 2021 (publication date) through Nov 24, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jan 26, 2021; 13(1): 30-48
Published online Jan 26, 2021. doi: 10.4252/wjsc.v13.i1.30

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Figure 2 Schematic representation of the adipocyte-to-myofibroblast transition process. In a pro-fibrotic microenvironment, both mature adipocytes de-differentiated into preadipocytes and undifferentiated adipose-derived stem cells (ADSCs) can give rise to pro-fibrotic myofibroblasts through adipocyte-to-myofibroblast transition. ADSCs: Adipose-derived stem cells; AMT: Adipocyte-to-myofibroblast transition; α-SMA: α-Smooth muscle actin; ECM: Extracellular matrix.

Citation: Rosa I, Romano E, Fioretto BS, Matucci-Cerinic M, Manetti M. Adipose-derived stem cells: Pathophysiologic implications vs therapeutic potential in systemic sclerosis. World J Stem Cells 2021; 13(1): 30-48
URL: https://www.wjgnet.com/1948-0210/full/v13/i1/30.htm
DOI: https://dx.doi.org/10.4252/wjsc.v13.i1.30