Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jan 26, 2021; 13(1): 30-48
Published online Jan 26, 2021. doi: 10.4252/wjsc.v13.i1.30
Adipose-derived stem cells: Pathophysiologic implications vs therapeutic potential in systemic sclerosis
Irene Rosa, Eloisa Romano, Bianca Saveria Fioretto, Marco Matucci-Cerinic, Mirko Manetti
Irene Rosa, Mirko Manetti, Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, Florence 50134, Italy
Eloisa Romano, Bianca Saveria Fioretto, Marco Matucci-Cerinic, Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence 50134, Italy
Author contributions: Rosa I and Romano E contributed equally to this work; Rosa I and Romano E wrote the paper; Fioretto BS prepared the figures and tables; Matucci-Cerinic M edited the paper; Manetti M coordinated the writing of the paper and edited the paper; all authors have read and approve the final manuscript.
Conflict-of-interest statement: Authors of this manuscript have no conflicts of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mirko Manetti, PhD, Assistant Professor, Department of Experimental and Clinical Medicine, Section of Anatomy and Histology, University of Florence, Largo Brambilla 3, Florence 50134, Italy. mirko.manetti@unifi.it
Received: July 8, 2020
Peer-review started: July 8, 2020
First decision: December 1, 2020
Revised: December 4, 2020
Accepted: December 11, 2020
Article in press: December 11, 2020
Published online: January 26, 2021
Processing time: 196 Days and 11.6 Hours
Core Tip

Core Tip: Adipose-derived stem cells (ADSCs) represent a promising cell source for cell-based therapy in the treatment of systemic sclerosis (SSc), but at the same time, they may be involved in the disease pathogenesis. In this review, the current status of fat grafting and autologous stromal vascular fraction/ADSC-based therapeutic applications as well as SSc-ADSC functional characterization and possible implication in disease-related fibrosis are discussed.