Brain stem cells as the cell of origin in glioma

Figure 1 Targeted oncogenesis in the neuroglial cellular hierarchy. (A) Neurogenesis in the adult mammalian brain; (B) Summary of murine models that targeted selected cell types for the purposes of discovering the glioma cell of origin. Horizontal bars in (B) correlate to the representative cell types in (A). ¹Experimental results by authors suggest differentiated progeny acted as the cell of mutation and de-differentiated before forming a tumor; ²Lack of lineage trace, distinguishing cell of mutation from cell of origin is inconclusive despite tumor forming capacity of differentiated progeny. Partially adapted from Ref. [8,48]. SVZ: Subventricular zone; NSCs: Neural stem cells; TAP: Transit amplifying progenitors.