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World J Stem Cells. Jan 26, 2014; 6(1): 43-52
Published online Jan 26, 2014. doi: 10.4252/wjsc.v6.i1.43
Published online Jan 26, 2014. doi: 10.4252/wjsc.v6.i1.43
Brain stem cells as the cell of origin in glioma
Aram S Modrek, Medical Scientist Training Program, New York University School of Medicine, New York, NY 10016, United States
Aram S Modrek, N Sumru Bayin, Dimitris G Placantonakis, Department of Neurosurgery, New York University School of Medicine, New York, NY 10016, United States
Dimitris G Placantonakis, Kimmel Center for Stem Cell Biology, New York University School of Medicine, New York, NY 10016, United States
Dimitris G Placantonakis, Brain Tumor Center, New York University School of Medicine, New York, NY 10016, United States
Author contributions: Modrek AS, Bayin NS and Placantonakis DG conceived and wrote the manuscript.
Supported by The Medical Scientist Training Program at NYU School of Medicine to Modrek AS; NYSTEM Institutional training grant #CO26880 to Bayin NS; NIH/NINDS (1 R21 NS087241-01), the NYU Cancer Institute Developmental Projects Program and the NYU Clinical and Translational Science Institute (NYU CTSA grant #UL1TR000038 from the National Center for the Advancement of Translational Science NCATS, NIH) to Placantonakis DG
Correspondence to: Dimitris G Placantonakis, MD, PhD, Department of Neurosurgery, New York University School of Medicine, 530 First Avenue, Skirball 8R-303 New York, NY 10016, United States. dimitris.placantonakis@nyumc.org
Telephone: +1-212-2632441 Fax: +1-212-2638042
Received: October 10, 2013
Revised: November 6, 2013
Accepted: December 12, 2013
Published online: January 26, 2014
Processing time: 128 Days and 9.3 Hours
Revised: November 6, 2013
Accepted: December 12, 2013
Published online: January 26, 2014
Processing time: 128 Days and 9.3 Hours
Core Tip
Core tip: The origins of glioma are not well understood. We approach the topic by review of our knowledge concerning the different cell types found in the mammalian brain, we describe mouse models aiming to model gliomagenesis and highlight relevant clinical data. Our aim is to integrate these three areas to provide a comprehensive snapshot of progress made towards the discovery of the process driving glioma formation.