Perspectives on Schwann-like cells derived from bone marrow-mesenchymal stem cells: Advancing peripheral nerve injury therapies

Figure 1 Schematic representation of the transdifferentiation of bone marrow-derived mesenchymal stem cells into Schwann-like cells using different protocols and their potential in vivo application. Protocols involving chemical agents, growth factors, exosomes derived from various cell sources, and secreted factors from equine and rat peripheral nerves are used for the in vitro transdifferentiation of bone marrow-derived mesenchymal stem cells into Schwann-like cells. Studies involving the transplantation of Schwann-like cells into animal models generally use chemical agents and growth factors to induce transdifferentiation. Created with Biorender (https://BioRender.com/p72z610). BM-MSCs: Bone marrow-derived mesenchymal stem cells.