Perspectives on Schwann-like cells derived from bone marrow-mesenchymal stem cells: Advancing peripheral nerve injury therapies

doi:10.4252/wjsc.v17.i2.102702

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Feb 26, 2025 (publication date) through Feb 24, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Feb 26, 2025; 17(2): 102702
Published online Feb 26, 2025. doi: 10.4252/wjsc.v17.i2.102702

Perspectives on Schwann-like cells derived from bone marrow-mesenchymal stem cells: Advancing peripheral nerve injury therapies

Lucas Vinícius de Oliveira Ferreira, Rogério Martins Amorim

Lucas Vinícius de Oliveira Ferreira, Rogério Martins Amorim, Department of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu 18618-681, São Paulo, Brazil

Author contributions: Ferreira LVO and Amorim RM made equal contributions to this study. Ferreira LVO and Amorim RM prepared and wrote the manuscript; and all authors have read and approved the final manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Lucas Vinícius de Oliveira Ferreira, Department of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Prof. Dr. Walter Maurício Corrêa Street, s/n, Botucatu 18618-681, São Paulo, Brazil. lv.ferreira@unesp.br

Received: October 28, 2024
Revised: December 18, 2024
Accepted: January 18, 2025
Published online: February 26, 2025
Processing time: 121 Days and 10.6 Hours

Core Tip

Core Tip: Schwann-like cells (SLCs) derived from bone marrow-mesenchymal stem cells have emerged as a promising therapeutic approach for peripheral nerve regeneration. However, further in vitro and in vivo studies are needed to optimize transdifferentiation and transplantation methodologies, as well as to explore the efficacy of SLCs in different injury models. The development of strategies that integrate SLCs could enhance neuroregeneration, promoting cell survival and therapeutic success.