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World J Stem Cells. Apr 26, 2017; 9(4): 68-76
Published online Apr 26, 2017. doi: 10.4252/wjsc.v9.i4.68
Fifteen years of bone marrow mononuclear cell therapy in acute myocardial infarction
Miruna Mihaela Micheu, Maria Dorobantu
Miruna Mihaela Micheu, Maria Dorobantu, Department of Cardiology, Clinical Emergency Hospital of Bucharest, 014461 Bucharest, Romania
Author contributions: Both authors equally contributed to the conception of the paper, the literature review and analysis, drafting and to critically revising and editing the manuscript.
Conflict-of-interest statement: Authors declare no conflict of interests for this article. No financial support.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Miruna Mihaela Micheu, MD, PhD, Department of Cardiology, Clinical Emergency Hospital of Bucharest, Floreasca Street 8, 014461 Bucharest, Romania. mirunamicheu@yahoo.com
Telephone: +40-72-2451755
Received: January 6, 2017
Peer-review started: January 10, 2017
First decision: February 17, 2017
Revised: March 16, 2017
Accepted: April 18, 2017
Article in press: April 19, 2017
Published online: April 26, 2017
Processing time: 107 Days and 11.2 Hours
Core Tip

Core tip: Since the first successful bone marrow stem cells transplantation performed 15 years ago in a patient with acute myocardial infarction, we have witnessed a mounting body of data as regards this cutting-edge therapy. During the reporting period, conflicting results have been stated, scientific papers have been under investigation, strategies to enhance the stem cells regenerative potential have been applied and/or suggested, position papers and recommendations have been published. This review will analytically discuss each of the above topics, summarizing the current state of knowledge in the field.