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World J Stem Cells. Sep 26, 2016; 8(9): 279-287
Published online Sep 26, 2016. doi: 10.4252/wjsc.v8.i9.279
Racial disparity in colorectal cancer: Gut microbiome and cancer stem cells
Sachin Goyal, Pratima Nangia-Makker, Lulu Farhana, Yingjie Yu, Adhip PN Majumdar
Sachin Goyal, Pratima Nangia-Makker, Lulu Farhana, Yingjie Yu, Adhip PN Majumdar, Department of Internal Medicine, John D Dingell VA Medical Center, Detroit, MI 48201, United States
Sachin Goyal, Pratima Nangia-Makker, Lulu Farhana, Yingjie Yu, Adhip PN Majumdar, Department of Internal Medicine, Wayne State University, Detroit, MI 48201, United States
Pratima Nangia-Makker, Adhip PN Majumdar, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, United States
Author contributions: Goyal S, Nangia-Makker P and Majumdar APN contributed to conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version; Farhana L and Yu Y contributed to experimental work, literature review and analysis, and final approval of the final version.
Supported by National Institutes of Health, No. 1R21 CA175916; Department of Veteran Affairs, No. I101BX001927; and Metropolitan Detroit Research and Education Fund (MDREF) grants to Dr. Majumdar.
Conflict-of-interest statement: No potential conflicts of interest. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Adhip PN Majumdar, PhD, Professor of Medicine, Department of Internal Medicine, Wayne State University, 4646 John R, B-4238, Detroit, MI 48201, United States. a.majumdar@wayne.edu
Telephone: +1-313-5764460 Fax: +1-313-5761112
Received: May 27, 2016
Peer-review started: May 27, 2016
First decision: June 17, 2016
Revised: July 12, 2016
Accepted: July 20, 2016
Article in press: July 22, 2016
Published online: September 26, 2016
Core Tip

Core tip: The role of microbial dysbiosis and cancer stem cells (CSCs) in colorectal cancer (CRC) has been studied extensively, however, their implication in racial disparity is not well known. A number of recent studies have shown that different dietary patterns affect gut microbiome. Likewise, dietary patterns also affect intracellular regulatory events which may affect the function of CSCs. Our objective is to consolidate the available data, on the role of gut microbiome and CSCs in racial disparity in CRC, explore a link between them and lay a foundation for further advances.