Garg M. Epithelial plasticity in urothelial carcinoma: Current advancements and future challenges. World J Stem Cells 2016; 8(8): 260-267 [PMID: 27621760 DOI: 10.4252/wjsc.v8.i8.260]
Corresponding Author of This Article
Minal Garg, Msc, PhD, Assistant Professor, Department of Biochemistry, University of Lucknow, University Road, Lucknow 226007, India. minal14@yahoo.com
Research Domain of This Article
Oncology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Aug 26, 2016; 8(8): 260-267 Published online Aug 26, 2016. doi: 10.4252/wjsc.v8.i8.260
Epithelial plasticity in urothelial carcinoma: Current advancements and future challenges
Minal Garg
Minal Garg, Department of Biochemistry, University of Lucknow, Lucknow 226007, India
Author contributions: Garg M solely contributed to this paper.
Supported byDepartment of Science and Technology, Govt. of India, No. SR/H0/HS/0113-2010.
Conflict-of-interest statement: The author declares no potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Minal Garg, Msc, PhD, Assistant Professor, Department of Biochemistry, University of Lucknow, University Road, Lucknow 226007, India. minal14@yahoo.com
Telephone: +91-9335-820857
Received: March 20, 2016 Peer-review started: March 22, 2016 First decision: April 20, 2016 Revised: April 25, 2016 Accepted: June 27, 2016 Article in press: June 29, 2016 Published online: August 26, 2016 Processing time: 153 Days and 16.1 Hours
Core Tip
Core tip: A subset of bladder cancer cells, known as urothelial cancer stem cells, have abilities to self-renew, generate tumor heterogeneity via differentiation, and are actually responsible for tumor relapse and metastasis formation. Delineating the mechanistic complexity between epithelial plasticity and cancer stemness in malignant transformation of urothelial carcinoma provides the basis for designing rational therapies. Differentiation and elimination therapies targeting the potential biomarkers could prove to be clinically beneficial by suppressing the cancer stemness and inhibiting epithelial-to-mesenchymal transition phenotype and would provide novel opportunities for targeted therapeutic approaches in the clinical management of patients.
