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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Aug 26, 2016; 8(8): 243-250
Published online Aug 26, 2016. doi: 10.4252/wjsc.v8.i8.243
Published online Aug 26, 2016. doi: 10.4252/wjsc.v8.i8.243
Targeting stem cells by radiation: From the biological angle to clinical aspects
Alexis Vallard, Sophie Espenel, Jean-Baptiste Guy, Yaoxiong Xia, Anis El Meddeb Hamrouni, Majed Ben Mrad, Chloé Rancoule, Nicolas Magné, Department of Radiotherapy, Lucien Neuwirth Cancer Institute, 42271 Saint-Priest en Jarez, France
Jean-Baptiste Guy, Claire Rodriguez-Lafrasse, Nicolas Magné, Laboratoire de Radiobiologie Cellulaire et Moléculaire, CNRS UMR 5822, Institut de Physique Nucléaire de Lyon, 69622 Villeurbanne, France
Peng Diao, Department of Radiation Oncology, Sichuan Cancer Hospital, Chengdu 610041, Sichuan Province, China
Alexander Tuan Falk, Department of Radiotherapy, Centre Antoine Lacassagne, 06100 Nice, France
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: Authors declare they have no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Nicolas Magné, MD, PhD, Department of Radiotherapy, Lucien Neuwirth Cancer Institute, 108 bis, Avenue Albert Raimond, BP 60008, 42271 Saint-Priest en Jarez, France. nicolas.magne@icloire.fr
Telephone: +33-04-77917434 Fax: +33-04-77917197
Received: April 27, 2016
Peer-review started: April 28, 2016
First decision: June 16, 2016
Revised: June 18, 2016
Accepted: July 11, 2016
Article in press: July 13, 2016
Published online: August 26, 2016
Processing time: 113 Days and 22.9 Hours
Peer-review started: April 28, 2016
First decision: June 16, 2016
Revised: June 18, 2016
Accepted: July 11, 2016
Article in press: July 13, 2016
Published online: August 26, 2016
Processing time: 113 Days and 22.9 Hours
Core Tip
Core tip: Radiotherapy is a cornerstone of anticancer treatments. However, significant levels of toxicity and recurrences are still reported. On the one hand, cancer stem cells have been recently suggested to be the root of radio-resistance, with strong pre-clinical rational. One the other hand, convincing pre-clinical data suggesting the importance of healthy tissue stem cells radiation-induced destruction in long term side effects of radiotherapy surfaced. This article provides an overview of the available literature analyzing from the clinical efficacy and toxicity perspective the interactions between stem cells and radiation. Significant improvement of radiotherapy toxicity/efficacy ratio is suggested.