Dennie D, Louboutin JP, Strayer DS. Migration of bone marrow progenitor cells in the adult brain of rats and rabbits. World J Stem Cells 2016; 8(4): 136-157 [PMID: 27114746 DOI: 10.4252/wjsc.v8.i4.136]
Corresponding Author of This Article
Jean-Pierre Louboutin, MD, PhD, Section of Anatomy, Department of Basic Medical Sciences, University of the West Indies, Mona Campus, West Road, Kingston 7, Jamaica. jplouboutin@hotmail.com
Research Domain of This Article
Neurosciences
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Apr 26, 2016; 8(4): 136-157 Published online Apr 26, 2016. doi: 10.4252/wjsc.v8.i4.136
Migration of bone marrow progenitor cells in the adult brain of rats and rabbits
Donnahue Dennie, Jean-Pierre Louboutin, David S Strayer
Donnahue Dennie, Jean-Pierre Louboutin, Section of Anatomy, Department of Basic Medical Sciences, University of the West Indies, Mona Campus, Kingston 7, Jamaica
David S Strayer, Department of Cell Biology, Anatomy and Pathology, Thomas Jefferson University, Philadelphia, PA 19107, United States
Author contributions: Dennie D and Louboutin JP contributed equally to writing the paper; Strayer DS supervised the work.
Conflict-of-interest statement: There is no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jean-Pierre Louboutin, MD, PhD, Section of Anatomy, Department of Basic Medical Sciences, University of the West Indies, Mona Campus, West Road, Kingston 7, Jamaica. jplouboutin@hotmail.com
Telephone: +876-3680554
Received: June 2, 2015 Peer-review started: June 7, 2015 First decision: July 6, 2015 Revised: October 19, 2015 Accepted: February 14, 2016 Article in press: February 16, 2016 Published online: April 26, 2016 Processing time: 316 Days and 9.7 Hours
Core Tip
Core tip: It was previously thought that the development of new neurons did not take place in the adult brain of higher vertebrates. There has been substantial progress in understanding neurogenesis in the adult brain during the last decade, showing that neural progenitor cells can induce neurogenesis, mainly in three areas: Subventricular zone, subgranular zone of the hippocampal dentate gyrus, and olfactory bulb. More recently, it has been shown that bone marrow progenitor cells can participate in neurogenesis in the adult brain. In this review, we discuss the mechanisms of the migration, differentiation, and maturation of bone marrow progenitor cells in the adult brain. We also consider the increase of adult neurogenesis following experimental seizures, provided that neuroinflammation is decreased by reducing the expression of chemokines, and consequently the related migration of inflammatory cells into the brain parenchyma.
