©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Updates in the pathophysiological mechanisms of Parkinson’s disease: Emerging role of bone marrow mesenchymal stem cells
Hanaa H Ahmed, Emad F Eskandar, Hadeer A Aglan, Hormones Department, Medical Research Division, National Research Centre, Giza 12622, Egypt
Ahmed M Salem, Mohamed A Ghazy, Biochemistry Department, Faculty of Science, Ain Shams University, Cairo 1156, Egypt
Hazem M Atta, Clinical Biochemistry Department, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Hazem M Atta, Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Cairo University, Kasralainy, Cairo 11562, Egypt
Abdel Razik H Farrag, Pathology Department, Medical Research Division, National Research Centre, Giza 12622, Egypt
Neveen A Salem, Narcotics, Ergogenic aids and Poisons Department, Medical Research Division, National Research Centre, Giza 12622, Egypt
Author contributions: Ahmed HH designed and coordinated the research as well as wrote the paper; Salem AM analyzed the data; Atta HM performed the isolation and preparation steps of bone marrow mesenchymal stem cells from rats; Eskandar EF participated in the designation of the research; Farrag AH performed the immunohistochemical examination and histopathological investigations; Ghazy MA performed the molecular investigations; Salem NA and Aglan HA participated in the induction of Parkinson’s disease in rats and treatment as well as performed the biochemical measurements.
Institutional review board statement: The study was reviewed and approved by the National Research Centre Institutional Review Board.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the National Research Centre, protocol number: (09-200).
Conflict-of-interest statement: The authors declared no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at email@example.com.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hanaa H Ahmed, PhD, Professor of Biochemistry, Hormones Department, Medical Research Division, National Research Centre, 33 El-Bohouth Street, Dokki, Giza 12622, Egypt. firstname.lastname@example.org
Telephone: +20-2-33335966 Fax: +20-2-33370931
Received: September 12, 2015
Peer-review started: September 16, 2015
First decision: November 7, 2015
Revised: February 1, 2016
Accepted: February 23, 2016
Article in press: February 24, 2016
Published online: March 26, 2016