Shihori Tanabe, Division of Risk Assessment, National Institute of Health Sciences, Tokyo 158-8501, Japan
Takeshi Kawabata, Laboratory of Protein Informatics, Institute for Protein Research, Osaka University, Suita 565-0871, Japan
Kazuhiko Aoyagi, Hiroki Sasaki, Department of Translational Oncology, National Cancer Center Research Institute, Tokyo 104-0045, Japan
Hiroshi Yokozaki, Department of Pathology, Kobe University of Graduate School of Medicine, Kobe 650-0017, Japan
Author contributions: Tanabe S performed the research and wrote the paper; Kawabata T analyzed the 3D structures of proteins; Aoyagi K, Yokozaki H and Sasaki H contributed critical revision of the manuscript for important intellectual content.
Institutional review board statement: Diffuse-type gastric cancer (GC) tissues were originally provided by the National Cancer Center Hospital after obtaining written informed consent from each patient and approval by National Cancer Center Institutional Review Board (ID: No.17-030). The existing data already available to the public were analyzed in the article.
Informed consent statement: Written informed consent from each patient were obtained.
Conflict-of-interest statement: To the best of the authors’ knowledge, no conflict of interest exists.
Data sharing statement: The microarray data for mesenchymal stem cells and diffuse-type gastric cancer are available to the public in NCBI’s Gene Expression Omnibus (GEO) database and are accessible via GEO Series accession number GSE7888 and GSE42252, respectively.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Shihori Tanabe, PhD, Division of Risk Assessment, National Institute of Health Sciences, 1-18-1, Kami-yoga, Setagaya-ku, Tokyo 158-8501, Japan. email@example.com
Telephone: +81-3-37001141 Fax: +81-3-37001145
Received: May 30, 2016
Peer-review started: June 3, 2016
First decision: July 5, 2016
Revised: July 22, 2016
Accepted: September 21, 2016
Article in press: September 22, 2016
Published online: November 26, 2016