Scarfì S. Use of bone morphogenetic proteins in mesenchymal stem cell stimulation of cartilage and bone repair. World J Stem Cells 2016; 8(1): 1-12 [PMID: 26839636 DOI: 10.4252/wjsc.v8.i1.1]
Corresponding Author of This Article
Sonia Scarfì, PhD, Associate Professor of Molecular Biology, Department of Earth, Environment and Life Sciences, University of Genova, Via Pastore 3, 16132 Genova, Italy. soniascarfi@unige.it
Research Domain of This Article
Research & Experimental Medicine
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Jan 26, 2016; 8(1): 1-12 Published online Jan 26, 2016. doi: 10.4252/wjsc.v8.i1.1
Use of bone morphogenetic proteins in mesenchymal stem cell stimulation of cartilage and bone repair
Sonia Scarfì
Sonia Scarfì, Department of Earth, Environment and Life Sciences, University of Genova, 16132 Genova, Italy
Author contributions: Scarfì S solely contributed to this paper.
Conflict-of-interest statement: The author declares no conflict of interest for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sonia Scarfì, PhD, Associate Professor of Molecular Biology, Department of Earth, Environment and Life Sciences, University of Genova, Via Pastore 3, 16132 Genova, Italy. soniascarfi@unige.it
Telephone: +39-010-35338227 Fax: +39-010-354415
Received: August 21, 2015 Peer-review started: August 24, 2015 First decision: October 13, 2015 Revised: December 4, 2015 Accepted: December 18, 2015 Article in press: December 21, 2015 Published online: January 26, 2016 Processing time: 150 Days and 15.3 Hours
Core Tip
Core tip: Since their first identification, bone morphogenetic proteins (BMPs) have attracted the attention for their potential therapeutic use in tissue engineering and biomedical regenerative therapies. In particular, BMP2 and BMP7 have been successfully used in the treatment of a number of cartilage and bone defects, although these strategies present a certain number of concerning side effects. Also in the field of mesenchymal stem cell (MSC) biology there is a continually growing interest, especially in the regulation of their differentiation, and in demonstrating their utility in tissue engineering. The review focuses on the current knowledge of BMP physiological roles in MSC biology and differentiation capacities. In particular it highlights the potentialities of the concomitant clinical use of BMPs and MSCs in cartilage and bone tissue repair.
