Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2015; 7(8): 1127-1136
Published online Sep 26, 2015. doi: 10.4252/wjsc.v7.i8.1127
Autologous tissue patch rich in stem cells created in the subcutaneous tissue
Ignacio Garcia-Gomez, Krishnamurthy P Gudehithlu, Jose A L Arruda, Ashok K Singh
Ignacio Garcia-Gomez, Jose A L Arruda, Ashok K Singh, Division of Nephrology, Hektoen Institute of Medicine, Chicago, IL 60612, United States
Krishnamurthy P Gudehithlu, Jose A L Arruda, Ashok K Singh, John H. Stroger, Jr. Hospital of Cook County, Chicago, IL 60612, United States
Jose A L Arruda, Ashok K Singh, Division of Nephrology, Department of Medicine, University of Illinois Medical Center at Chicago and the Chicago VA Medical Center, Chicago, IL 60612, United States
Author contributions: Garcia-Gomez I and Singh AK performed experiments, interpreted data, and drafted the manuscript; Gudehithlu KP provided important technical help in designing the foreign body implants; Arruda JAL critically interpreted data and reviewed the manuscript.
Institutional animal care and use committee statement: All the animal experiments were reviewed and approved by the Institutional Animal Care and Use Committee of the John H. Stroger, Jr. Hospital of Cook County.
Conflict-of-interest statement: None.
Data sharing statement: None.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ashok K Singh, PhD, John H. Stroger, Jr. Hospital of Cook County, 1969 West Ogden Avenue, Chicago, IL 60612, United States. singhashok100@yahoo.com
Telephone: +1-312-8644613 Fax: +1-312-8649569
Received: November 26, 2014
Peer-review started: November 29, 2014
First decision: December 26, 2014
Revised: June 25, 2015
Accepted: July 16, 2015
Article in press: July 17, 2015
Published online: September 26, 2015
Processing time: 303 Days and 13.6 Hours
Core Tip

Core tip: While much progress has been made in man-made tissue patches for organ repair, their clinical success has been bogged down by their inability to get promptly vascularized in vivo. We describe a methodology for creating tissue patches of several possible shapes/sizes in the subcutaneous tissue utilizing the foreign body reaction. These patches are endowed with a rich capillary network, abundant mesenchymal stem cells, and other accessory cells that support the viability of the tissue. Such in vivo generated patches for tissue repair promise to be safer, more readily vascularized, and stable for longer period in the body.