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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2015; 7(8): 1090-1108
Published online Sep 26, 2015. doi: 10.4252/wjsc.v7.i8.1090
Published online Sep 26, 2015. doi: 10.4252/wjsc.v7.i8.1090
Complement activation in the context of stem cells and tissue repair
Ingrid U Schraufstatter, Sophia K Khaldoyanidi, Richard G DiScipio, Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, United States
Ingrid U Schraufstatter, Richard G DiScipio, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, United States
Author contributions: Schraufstatter IU, Khaldoyanidi SK, and DiScipio RG all wrote the manuscript.
Supported by The grants R21 HL094878 and R21AI10950 to IUS and RGD.
Conflict-of-interest statement: None of the authors have any financial interest to declare.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Ingrid U Schraufstatter, MD, Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121, United States. ischraufstatter@tpims.org
Telephone: +1-858-5973898 Fax: +1-858-5973898
Received: November 27, 2014
Peer-review started: November 29, 2014
First decision: January 20, 2015
Revised: July 3, 2015
Accepted: July 24, 2015
Article in press: July 27, 2015
Published online: September 26, 2015
Peer-review started: November 29, 2014
First decision: January 20, 2015
Revised: July 3, 2015
Accepted: July 24, 2015
Article in press: July 27, 2015
Published online: September 26, 2015
Core Tip
Core tip: This review article provides an overview over the scenarios, where complement activation contributes to tissue repair and regeneration through its effect on stem and progenitor cells, which is an area that needs further investigation.