Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jun 26, 2015; 7(5): 806-814
Published online Jun 26, 2015. doi: 10.4252/wjsc.v7.i5.806
Corneal stem cells and tissue engineering: Current advances and future perspectives
Aline Lütz de Araujo, JoséÁlvaro Pereira Gomes
Aline Lütz de Araujo, Clínica Lentecor, Porto Alegre - RS 90570041, Brazil
JoséÁlvaro Pereira Gomes, Department of Ophthalmology and Visual Sciences, Universidade Federal de São Paulo, São Paulo - SP 04023062, Brazil
Author contributions: de Araujo AL and Gomes JÁP equally contributed to this paper.
Conflict-of-interest: The authors declare no potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Aline Lütz de Araujo, MD, Clínica Lentecor, Rua Doutor Timóteo, 727/801, Porto Alegre - RS 90570041, Brazil.
Telephone: +55-51-30227600 Fax: +55-51-33388080
Received: August 29, 2014
Peer-review started: August 30, 2014
First decision: December 17, 2014
Revised: January 5, 2015
Accepted: April 16, 2015
Article in press: April 20, 2015
Published online: June 26, 2015
Core Tip

Core tip: Corneal stem cell-based therapies represent a novel strategy that may substitute conventional corneal transplantation, albeit there are many challenges ahead given the singularities of each cellular layer of the cornea. To date, the most widespread clinical approach to regenerative medicine in the eye has been the utilization of limbal stem cells for ocular surface diseases. New therapeutic strategies are under development due to the recent identification of corneal stromal stem cells and corneal endothelial cell progenitors. This review recapitulates the current advances and discusses future perspectives in the field.