Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2015; 7(4): 711-727
Published online May 26, 2015. doi: 10.4252/wjsc.v7.i4.711
Epidermal stem cells and skin tissue engineering in hair follicle regeneration
María Eugenia Balañá, Hernán Eduardo Charreau, Gustavo José Leirós
María Eugenia Balañá, Gustavo José Leirós, Fundación Pablo Cassará -Instituto de Ciencia y Tecnología Dr. César Milstein, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Saladillo 2468 C1440FFX, Ciudad de Buenos Aires, Argentina
Hernán Eduardo Charreau, Technology Intelligence Unit, Clarke, Modet & C°, Lavalle 190, 3° Piso, C1047AAD Buenos Aires, Argentina
Author contributions: Balañá ME, Charreau HE and Leirós GJ substantially contributed to conception and design, acquisition of data, analysis and interpretation of data.
Supported by the Agencia Nacional de Producción Científica y Tecnológica (ANPCyT), No. ANR BIO 0032/10.
Conflict-of-interest: The authors state no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Dr. María Eugenia Balañá, Fundación Pablo Cassará, Instituto de Ciencia y Tecnología Dr. Cesar Milstein, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Saladillo 2468 C1440FFX, Ciudad de Buenos Aires, Argentina.
Telephone: +54-11-41054127 Fax: +54-11-46874065
Received: August 27, 2014
Peer-review started: August 28, 2014
First decision: September 4, 2014
Revised: October 2, 2014
Accepted: February 4, 2015
Article in press: February 9, 2015
Published online: May 26, 2015
Core Tip

Core tip: Loss of hair follicles caused by injuries or pathologies affects the patients’ psychological well-being and endangers inherent functions of the skin. Different experimental strategies and approaches to obtain mature hair follicles have been designed based upon current knowledge of the epithelial and dermal cells involved in embryonic hair generation and adult hair cycling, and in the epithelial-mesenchymal interactions among them. This review summarizes the current advances in hair follicle neogenesis and regeneration, with emphasis on those involving neogenesis of hair follicles in adults from isolated cells and tissue engineering as well as an analysis on patent trends in this field.