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World J Stem Cells. Mar 26, 2015; 7(2): 512-520
Published online Mar 26, 2015. doi: 10.4252/wjsc.v7.i2.512
Molecular mechanism of extrinsic factors affecting anti-aging of stem cells
Tzyy Yue Wong, Mairim Alexandra Solis, Ying-Hui Chen, Lynn Ling-Huei Huang
Tzyy Yue Wong, Mairim Alexandra Solis, Ying-Hui Chen, Lynn Ling-Huei Huang, Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 70101, Taiwan
Lynn Ling-Huei Huang, Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
Author contributions: Wong TY, Solis MA, Chen YH and Huang LLH wrote this paper.
Supported by A grant from the National Science Council, Taiwan.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Lynn Ling-Huei Huang, PhD, Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan. lynn@mail.ncku.edu.tw
Telephone: +886-6-2757575 Fax: +886-6-2080165
Received: August 25, 2014
Peer-review started: August 25, 2014
Revised: October 2, 2014
Accepted: November 17, 2014
Article in press: November 19, 2014
Published online: March 26, 2015
Processing time: 206 Days and 18.2 Hours
Core Tip

Core tip: This review approaches anti-aging from aspect of stem cells. Stem cells may interact directly with their extracellular surroundings through caveolin-1, a lipid raft protein, to carry out and maintain stem cell functions. Mechanisms through hypoxia-inducible factor-1, glycolysis, and epigenetic regulators such as p300, protein inhibitors of activated Stats and H19 play crucial role in stem cell quiescence, and anti-aging regulations. Conversely, genomic instability such as DNA double-strand-breaks modulate cellular aging through the mammalian target of rapamycin pathway, which may lead to decreased lifespan.