Review
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Mar 26, 2015; 7(2): 243-252
Published online Mar 26, 2015. doi: 10.4252/wjsc.v7.i2.243
Substrates for clinical applicability of stem cells
Sanjar Enam, Sha Jin
Sanjar Enam, Sha Jin, Department of Biomedical Engineering, Thomas J Watson School of Engineering and Applied Sciences, State University of New York in Binghamton, Binghamton, NY 13902, United States
Author contributions: Enam S and Jin S contributed to this paper.
Conflict-of-interest: The authors declare that there are no conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Sha Jin, PhD, Department of Biomedical Engineering, Thomas J Watson School of Engineering and Applied Sciences, State University of New York in Binghamton, 4400 Vestal Parkway East, Binghamton, NY 13902, United States. sjin@binghamton.edu
Telephone: +1-607-7775082 Fax: +1-607-7775780
Received: July 17, 2014
Peer-review started: July 18, 2014
First decision: September 28, 2014
Revised: October 23, 2014
Accepted: December 18, 2014
Article in press: December 19, 2014
Published online: March 26, 2015
Processing time: 246 Days and 2.1 Hours
Core Tip

Core tip: This review article highlights numerous extracellular matrix proteins, peptide and polymer based substrates, scaffolds and hydrogels that have been pioneered for human pluripotent stem cell self-renewal for stem cell-based therapy. The benefits and shortcomings of these substrates as well as future direction that can bring the benefits of regenerative medicine to clinical settings are discussed.