Baptista LS, Silva KR, Borojevic R. Obesity and weight loss could alter the properties of adipose stem cells? World J Stem Cells 2015; 7(1): 165-173 [PMID: 25621116 DOI: 10.4252/wjsc.v7.i1.165]
Corresponding Author of This Article
Leandra S Baptista, PhD, Laboratório de bioengenharia de tecidos, Instituto Nacional de Metrologia, Qualidade e Tecnologia (Inmetro), Av. Nossa Senhora das Graças, 50 - Xerém, Duque de Caxias 25250-020, Brazil. leandra.baptista@gmail.com
Research Domain of This Article
Cell Biology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Jan 26, 2015; 7(1): 165-173 Published online Jan 26, 2015. doi: 10.4252/wjsc.v7.i1.165
Obesity and weight loss could alter the properties of adipose stem cells?
Leandra S Baptista, Karina R Silva, Radovan Borojevic
Leandra S Baptista, Radovan Borojevic, Laboratório de bioengenharia de tecidos, Instituto Nacional de Metrologia, Qualidade e Tecnologia (Inmetro), Duque de Caxias 25250-020, Brazil
Leandra S Baptista, Núcleo Multidisciplinar de Pesquisa em Xerém (Numpex-Bio), Universidade Federal do Rio de Janeiro (UFRJ), Campus de Xerém, Rio de Janeiro 21941-590, Brazil
Karina R Silva, Radovan Borojevic, Programa de Pós-graduação em Clínica Médica, Universidade Federal do Rio de Janeiro (UFRJ), Hospital Universitário Clementino Fraga Filho (HUCFF), Rio de Janeiro 21941-590, Brazil
Author contributions: Baptista LS and Borojevic R substantially contributed to the concept of the review and finalized the text; Baptista LS and Silva KR contributed to the text and designed the images.
Supported by Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Leandra S Baptista, PhD, Laboratório de bioengenharia de tecidos, Instituto Nacional de Metrologia, Qualidade e Tecnologia (Inmetro), Av. Nossa Senhora das Graças, 50 - Xerém, Duque de Caxias 25250-020, Brazil. leandra.baptista@gmail.com
Telephone: +55-21-26799834 Fax: +55-21-26799837
Received: July 26, 2014 Peer-review started: July 26, 2014 First decision: August 28, 2014 Revised: September 22, 2014 Accepted: October 23, 2014 Article in press: December 16, 2014 Published online: January 26, 2015 Processing time: 172 Days and 0.3 Hours
Core Tip
Core tip: In this mini-review, we summarize recent aspects regarding obese subcutaneous adipose tissue with a focus in adipogenic and secretory capacities of adipose stem cells. In particular, we discuss how the occurrence of obesity and weight loss could alter the properties of stem cells and the consequences of using adipose-derived stem cells in regenerative medicine. Our previous results reveal that, after massive weight loss subsequent to bariatric surgery, stem cells retain an adipogenic memory besides a predominance of larger blood vessels in subcutaneous adipose tissue. Inflammatory subcutaneous adipose tissue microenvironment found in obese patients and even the massive weight loss could alter adipose tissue-derived stem cells phenotype to a non-healthy state.
