Bhatia P, Tsumagari K, Abd Elmageed ZY, Friedlander P, Buell JF, Kandil E. Stem cell biology in thyroid cancer: Insights for novel therapies. World J Stem Cells 2014; 6(5): 614-619 [PMID: 25426258 DOI: 10.4252/wjsc.v6.i5.614]
Corresponding Author of This Article
Emad Kandil, MD, FACS, Departments of Surgery, Tulane University School of Medicine, 1430 Tulane Avenue, SL 59, New Orleans, LA 70112, United States. ekandil@tulane.edu
Research Domain of This Article
Surgery
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
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World J Stem Cells. Nov 26, 2014; 6(5): 614-619 Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.614
Stem cell biology in thyroid cancer: Insights for novel therapies
Parisha Bhatia, Koji Tsumagari, Zakaria Y Abd Elmageed, Paul Friedlander, Joseph F Buell, Emad Kandil
Parisha Bhatia, Koji Tsumagari, Zakaria Y Abd Elmageed, Joseph F Buell, Emad Kandil, Departments of Surgery, Tulane University School of Medicine, New Orleans, LA 70112, United States
Paul Friedlander, Emad Kandil, Departments of Otolaryngology, Tulane University School of Medicine, New Orleans, LA 70112, United States
Author contributions: Tsumagari K designed research and performed research; Abd Elmageed ZY contributed new reagents and analytic tools; Kandil E, Friedlander P, Buell JF analyzed and revised data; Bhatia P wrote the paper.
Correspondence to: Emad Kandil, MD, FACS, Departments of Surgery, Tulane University School of Medicine, 1430 Tulane Avenue, SL 59, New Orleans, LA 70112, United States. ekandil@tulane.edu
Telephone: +1-504-9885454 Fax: +1-504-9887846
Received: July 27, 2014 Revised: September 12, 2014 Accepted: September 17, 2014 Published online: November 26, 2014 Processing time: 62 Days and 23.9 Hours
Core Tip
Core tip: The concept of cancer stem cells in thyroid gland tumors has recently evolved. Since this sub-population of cells appear to have a potential for self-renewal and cell differentiation, their role envisions newer ideas in the field of anti-cancer therapy and regenerative medicine. The controversies have been raised for their origin in different cell lines and effectiveness in thyroid pathologies including chemo- and radio-resistant thyroid cancer. Newer concepts like epithelial-mesenchymal transition have been investigated to define its role in metastatic activity. Literature discusses various methods to target these cells by interfering signaling pathways, destruction of niche and other factors which facilitate and sustain tumor growth.
